SEMINARIOS AREA QUÍMICA ORGÁNICA FBIOYF/IQUIR

SEMINARIO QUÍMICA ORGÁNICA 03-08-20 TÍTUL O : "Total Synthesis and Biological Evaluation of Tiancimycins A and B, Yangpumicin A, and Related Anthraquinone-Fused Enediyne Antitumor Antibiotics" FUENTE :  K. C. Nicolaou et al. J. Am. Chem. Soc. 2020 , 142 , 2549−2561. EXPOSITOR : Qco. Santiago Bolivar DÍA, HORA y LUGAR : Lunes 03 de agosto de 2020, 17:30 h, Plataforma MEET GOOGLE. Link : meet.google.com/ksi-cypi-pif LinkPresentación :  https://drive.google.com/file/d/1rniNOwHzP56xBLBp1Fg4cBJriLx9NJF3/view?ts=5f288ddf RESUMEN : The family of anthraquinone-fused enediyne antitumor antibiotics was established by the discovery of dynemicin A and deoxy- dynemicin A. It was then expanded, first by the isolation of uncialamycin, and then by the addition to the family of tiancimycins A−F and yangpumicin A. This family of natural products provides opportunities in total synthesis, biology, and medicine due to their novel and challenging molecular structures, intriguing biologica...

SEMINARIO QUÍMICA ORGÁNICA 27-07-20 TÍTUL O : "Enantioselective Diarylcarbene Insertion into Si-H Bonds Induced by Electronic Properties of the Carbenes" FUENTE :  Liang-liang Yang, Declan Evans, Bin Xu, Wen-Tao Li, Mao-Lin Li, Shou-Fei Zhu, K. N. Houk, and Qi-Lin Zhou   J. Am. Chem. Soc.  2020 ,  142 , 12394-12399, DOI :10.1021/jacs.0c04725. EXPOSITOR : Lic. Iván Cortés DÍA, HORA y LUGAR : Martes 28 de julio de 2020, 14 h, Plataforma MEET GOOGLE. Link :  meet.google.com/vod-ikcf-zzj RESUMEN : Catalytic enantioselection usually depends on differences in steric interactions between prochiral substrates and a chiral catalyst. We have discovered a carbene Si–H insertion in which the enantioselectivity depends primarily on the electronic characteristics of the carbene substrate, and the log(er) values are linearly related to Hammett parameters. A new class of chiral tetraphosphate dirhodium catalysts was developed; it shows excellent activity and enantioselecti...