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EJERCICIOS ORGANICA

Ejercicio 06-04-20
eFFECTOR Therapeutics, Inc., San Diego, CA (US) US009957277B2 (2018)

Ejercicio 05-08-19

J. Am. Chem. Soc. 1999, 121, 5467.

Ejercicio 22-07-19



J. Am. Chem. Soc. 1939, 61, 2890.

Ejercicio 24-06-19


Ejercicio 27-05-19

Tetrahedron 2005, 61, 3659.

Ejercicio 20-05-19

J. Am. Chem. Soc. 1969, 91, 7780.

Ejercicio 29-04-19

J. Am. Chem. Soc. 1977, 99, 549.

Ejercicio 15-04-19


Ejercicio 08-04-19



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24° SEMINARIO QUÍMICA ORGÁNICA IQUIR 2024

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18° SEMINARIO QUÍMICA ORGÁNICA IQUIR 2024

SEMINARIO QUÍMICA ORGÁNICA 16-9-24 EXPOSITOR :  Dr. Enrique L. Larghi TÍTULO :   " Total Synthesis of Isoxeniolide A " FUENTE :     Leo Betschart and Karl-Heinz Altmann. Angew. Chem. Int. Ed. 2024, 63, e202315423, DOI: 10.1002/anie.202315423. DÍA, HORA y LUGAR : Lunes 16 de septiembre de 2024, 14:00 h, Aula 18 y virtual. Modalidad virtual, Link :  meet.google.com/hjn-ygro-twf  ( Plataforma MEET GOOGLE) Resumen : The total synthesis of the xenicane-type marine natural product isoxeniolide A has been accomplished through a ring-opening/ring-closing metathesis sequence and an intramolecular Nozaki–Hiyama–Kishi (NHK) reaction to forge the nine-membered ring as the key enabling steps. The NHK cyclization was highly diastereoselective and provided the oxabicyclo[7.4.0]tridecene core of isoxeniolide A as a single stereoisomer.

10° SEMINARIO QUÍMICA ORGÁNICA IQUIR 2024

SEMINARIO QUÍMICA ORGÁNICA 24-6-24 EXPOSITOR :  Qco. Miguel Villarreal Parra TÍTULO :   " Nitro-Group-Containing Drugs " FUENTE :   DOI: https://doi.org/10.1021/acs.jmedchem.8b00147 Kunal Nepali, Hsueh-Yun Lee, and Jing-Ping Liou* J. Med. Chem. 2019, 62, 6, 2851–2893. DÍA, HORA y LUGAR : Lunes 24 de junio de 2024, 14:00 h, Aula 18 y virtual. Modalidad virtual, Link :  meet.google.com/hjn-ygro-twf  ( Plataforma MEET GOOGLE) Resumen :  The nitro group is considered to be a versatile and unique functional group in medicinal chemistry. Despite a long history of use in therapeutics, the nitro group has toxicity issues and is often categorized as a structural alert or a toxicophore, and evidence related to drugs containing nitro groups is rather contradictory. In general, drugs containing nitro groups have been extensively associated with mutagenicity and genotoxicity. In this context, efforts toward the structure–mutagenicity or structure–genotoxicity relationsh...