SEMINARIOS AREA QUÍMICA ORGÁNICA FBIOYF/IQUIR

SEMINARIO QUÍMICA ORGÁNICA 11-5-26 EXPOSITORA :  Dra.  Carina M. L. Delpiccolo TÍTULO :   " Idler Compounds: A Simple Protocol for Openly Sharing Fridge Contents for Cross-Screening ". FUENTE : Rebecka Isaksson, Eve M. Carter, Charlotte K. Hind, J. Mark Sutton, Hazel Rudgyard, Adam H. Roberts, Christopher W. Moon, Yinuo Wang, Todd Group Researchers, Sandra Codony, Antón L. Martínez, Joanna Bacon, and Matthew H. Todd J. Med. Chem. , 2026 , 69 , 2453-2461. DÍA, HORA y LUGAR : Lunes 11 de mayo de 2026, 14:00 h, Aula de graduados y virtual. Modalidad virtual, Link :  meet.google.com/wpi-ujuz-rok. Resumen : Academic drug discovery laboratories tend to accumulate collections of compounds with great potential value that merely reside in fridges and freezers. Cross screening these libraries against alternative targets holds significant potential for uncovering novel hits, but in the academic setting compound collections are rarely used, and shared, in this way. We present a...

SEMINARIO QUÍMICA ORGÁNICA 4-5-26 EXPOSITOR :  Qco.  Miguel R. Villarreal Parra TÍTULO :   " Quinazolin‐4(3H)‐One‐Based New Glitazones as Dual Inhibitors of α‐Glucosidase and Aldose Reductase: Comprehensive Approaches for Managing Diabetes Mellitus and Its Complications ". FUENTE : Tokalı, F.S., Demir, Y., Ateşoğlu, Ş., Tokalı, P. and Şenol, H. Archiv der Pharmazie, 2025, 358: e70033 https://doi.org/10.1002/ardp.70033 . DÍA, HORA y LUGAR : Lunes 4 de mayo de 2026, 14:00 h, Aula de graduados y virtual. Modalidad virtual, Link :  meet.google.com/wpi-ujuz-rok. Resumen :   A series of novel glitazones containing thiazolidine-2,4-dione and quinazolin-4(3H)-one moieties were synthesized to explore their potential as dual inhibitors of aldose reductase (ALR2) and α-glucosidase (α-Glu), two key enzymes involved in diabetes and its complications. In vitro assays revealed that compounds 8 (cyclohexyl substituted), 9 (phenethyl substituted), and 11 (phenyl substituted) e...

SEMINARIO QUÍMICA ORGÁNICA 27-4-26 EXPOSITOR :  Qco.  Arturo Mendoza Salgado TÍTULO :   " Total Synthesis of (±)-Cristaxenicin A: Construction of Nine-Membered Ring by Eschenmoser–Claisen/Cope Rearrangement Cascade ". FUENTE :   W.Kiuchi, Y.Tsunoda, K.Ishikura, K.Kato, J.Takino, T.Suzuki, K.Tanino, Angew. Chem. Int. Ed.  2026 , 65 , e24855. https://doi.org/10.1002/anie.202524855 . DÍA, HORA y LUGAR : Lunes 27 de abril de 2026, 14:00 h, Aula de graduados y virtual. Modalidad virtual, Link :  meet.google.com/wpi-ujuz-rok. Resumen :   Cristaxenicin A, a natural marine product with a skeleton consisting of a nine-membered carbocycle fused with a dihydropyran ring, displays strong antiprotozoal activity against Leishmania amazonensis and Trypanosoma congolense. The synthesis of cristaxenicin A is challenging because of its unique oxidation pattern at C11 and C20, the cis-cyclononane with a C5─C6 double bond, and the C1─C19 alkene moiety functionalized ...

SEMINARIO QUÍMICA ORGÁNICA 20-4-26 EXPOSITOR :  Dr. Ernesto G. Mata TÍTULO :   " Total Syntheses of Bryostatins ". FUENTE :   Guo, Q., Yang, Y., Zhang, H., Wang, D., Li, B., Jiang, D., ... & Song, Z. Angewandte Chemie , 2025 , 137 (14), e202423465. DÍA, HORA y LUGAR : Lunes 20 de abril de 2026, 14:00 h, Aula de graduados y virtual. Modalidad virtual, Link :  meet.google.com/wpi-ujuz-rok. Resumen : Bryostatin 1 34, produced by a bacterial symbiont of the marine bryozoan Begula neritina, has shown promise for the treatment of Alzheimer’s disease. This work reports the divergent total syntheses of bryostatins, obtaining 1.5 g of bryostatin 1 in the final three steps. Key methods include Ni-catalyzed reductive cross-coupling, flow-assisted light-induced radical addition, and a Prins cyclization for cis-Z selectivity. The syntheses require 20–22 linear steps (33–35 total) with overall yields of 3.3–4.5%.

SEMINARIO QUÍMICA ORGÁNICA 13-4-26 EXPOSITOR :  Lic. Darián Vazquez TÍTULO :   " Total syntheses of Tetrodotoxin and 9-epiTetrodotoxin ". FUENTE : Chen, P., Wang, J., Zhang, S. et al. Total syntheses of Tetrodotoxin and 9-epiTetrodotoxin. Nat Commun 15, 679 (2024). https://doi.org/10.1038/s41467-024-45037-0 . DÍA, HORA y LUGAR : Lunes 13 de abril de 2026, 14:00 h, híbrido. Modalidad presencial (Aula de graduados) y virtual, Link :  meet.google.com/wpi-ujuz-rok. Resumen : Tetrodotoxin and congeners are specific voltage-gated sodium channel blockers that exhibit remarkable anesthetic and analgesic effects. Here, we present a scalable asymmetric syntheses of Tetrodotoxin and 9-epiTetrodotoxin from the abundant chemical feedstock furfuryl alcohol. The optically pure cyclohexane skeleton is assembled via a stereoselective Diels-Alder reaction. The dense heteroatom substituents are established sequentially by a series of functional group interconversions on highly oxygenated ...

SEMINARIO QUÍMICA ORGÁNICA 6-4-26 EXPOSITOR : Lic. Lina V. López López TÍTULO :   " Late-Stage Functionalization of Amino Acids and Peptides ". FUENTE :  Trabajo de investigación de la presentadora. DÍA, HORA y LUGAR : Lunes 6 de abril de 2026, 14:00 h, Aula 12 y virtual. Modalidad virtual, Link :  meet.google.com/wpi-ujuz-rok. Resumen :  El seminario que se llevará a cabo presenta los resultados de la pasantía realizada el año pasado a través de una beca otorgada por la OPCW en Gif-Sur-Yvette (Francia), en el ICSN, bajo la supervisión del Dr. Philippe Dauban. El objetivo de este trabajo es establecer condiciones óptimas para la funcionalización selectiva de enlaces C–H en diversos aminoácidos, con el fin de extender estas metodologías a sistemas más complejos, como los péptidos.