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14º SEMINARIO QUÍMICA ORGÁNICA IQUIR 2026

SEMINARIO QUÍMICA ORGÁNICA 24-8-26 EXPOSITORA : Lic. Josefina Huck TÍTULO : " A Practical Start-Up Guide for Synthetic Chemists to Implement Design of Experiments (DoE) " FUENTE : Wall, B. J.; Koeritz, M. T.; Stanley, L. M.; VanVeller, B. ACS Catal. 2025, 15 (11), 8885–8893 . DÍA, HORA y LUGAR : Lunes 24 de agosto de 2026, 14:00 h, Aula de graduados y virtual. Modalidad virtual, Link : meet.google.com/wpi-ujuz-rok. Resumen : Experimental design in the synthetic chemistry community primarily focuses on optimizing reaction conditions by modifying one variable at a time (OVAT). Design of Experiments (DoE) methodology, already commonplace in the chemical industry, captures optimal reaction conditions while shrinking the number of experiments required. Additionally, DoE can provide interaction effects between variables that are not captured in OVAT optimizations. Despite the cost- and time-saving benefits that DoE can provide, it has not been widely adopted by the academic co...
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13º SEMINARIO QUÍMICA ORGÁNICA IQUIR 2026

SEMINARIO QUÍMICA ORGÁNICA 10-8-26 EXPOSITOR : Dr. Iván Cortés TÍTULO :   "Nickel Catalysis via SH2 Homolytic Substitution: The Double Decarboxylative Cross-Coupling of Aliphatic Acids " FUENTE :     Artem V. Tsymbal, Lorenzo Delarue Bizzini, David W. C. MacMillan; Nickel Catalysis via SH2 Homolytic Substitution: The Double Decarboxylative Cross-Coupling of Aliphatic Acids. Journal American Chemical Society 23 November 2022; 144 (46): 21278–21286. https://doi.org/10.1021/jacs.2c08989 . DÍA, HORA y LUGAR : Lunes 10 de agosto de 2026, 14:00 h, Aula de graduados y virtual. Modalidad virtual, Link : meet.google.com/wpi-ujuz-rok. Resumen : Cross-coupling platforms are traditionally built around a sequence of closed-shell steps, such as oxidative addition, transmetalation, and reductive elimination. Herein, we describe a dual photo/nickel catalytic manifold that performs cross-coupling via a complementary sequence involving free radical generation, radical sorting via selecti...
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12º SEMINARIO QUÍMICA ORGÁNICA IQUIR 2026

SEMINARIO QUÍMICA ORGÁNICA 3-8-26 EXPOSITOR : Lic. Enzo Centurión TÍTULO : " Ladderanes: stepping up as nonclassical ortho-substituted benzene bioisosteres " FUENTE :    Adak, S. et al. Ladderanes: stepping up as nonclassical ortho-substituted benzene bioisosteres. J. Am. Chem. Soc. 148, 23078–23087 (2026). https://doi.org/10.1021/jacs.6c05064. DÍA, HORA y LUGAR : Lunes 3 de agosto de 2026, 14:00 h, Aula de graduados y virtual. Modalidad virtual, Link : meet.google.com/wpi-ujuz-rok. Resumen :  Modulating the physicochemical properties of small-molecule active pharmaceutical ingredients (APIs) is a vital component of the drug discovery process. In recent years, investigations of the synthesis and application of saturated isosteres for aromatic rings have been growing and have often been shown to improve the properties of an API in matched pairs analysis. While saturated isosteres for para-substituted aromatic rings are well-established, replacing ortho-substituted rings,...
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11º SEMINARIO QUÍMICA ORGÁNICA IQUIR 2026

SEMINARIO QUÍMICA ORGÁNICA 27-7-26 EXPOSITOR :  Lic. Matías Krivoy TÍTULO : " Photochemical permutation of thiazoles, isothiazoles and other azoles " FUENTE :   Roure, B., Alonso, M., Lonardi, G. et al. Photochemical permutation of thiazoles, isothiazoles and other azoles. Nature 637, 860–867 (2025). https://doi.org/10.1038/s41586-024-08342-8 . DÍA, HORA y LUGAR : Lunes 27 de julio de 2026, 14:00 h, Aula de graduados y virtual. Modalidad virtual, Link : meet.google.com/wpi-ujuz-rok. Resumen : Thiazoles and isothiazoles are privileged motifs in drug and agrochemical discovery. The synthesis of these derivatives is generally approached, designed and developed on a case-by-case basis. Sometimes, the lack of robust synthesis methods to a given target can pose considerable difficulties or even thwart the preparation of specific derivatives for further study. Here we report a conceptually different approach in which photochemical irradiation can be used to alter the structure o...
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10º SEMINARIO QUÍMICA ORGÁNICA IQUIR 2026

SEMINARIO QUÍMICA ORGÁNICA 29-6-26 EXPOSITOR :  Qco. José Vaz Cardoso Machado TÍTULO : " Design, Synthesis, and Trypanosomicidal Evaluation of EugenolBased Azole Hybrids: Discovery of an In Vitro Active and Selective Compound. " FUENTE :   Qco.  José Vaz Cardoso Machado et al. , ACS Omega 2025 , 10 , 36, 41958–41974. DÍA, HORA y LUGAR : Lunes 29 de junio de 2026, 14:00 h, Aula de graduados y virtual. Modalidad virtual, Link : meet.google.com/wpi-ujuz-rok. Resumen :  Chagas disease, caused by Trypanosoma cruzi, remains a major public health concern in Latin America and beyond, with limited treatment options and high morbidity in chronic stages. Currently, benznidazole remains the first-line therapy for Chagas disease but exhibits considerable limitations, including dose-dependent toxicity and poor efficacy in long-term infections. In response to the pressing need for safer and more effective therapies, this study reports the design, synthesis, and biological evaluati...
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9º SEMINARIO QUÍMICA ORGÁNICA IQUIR 2026

SEMINARIO QUÍMICA ORGÁNICA 8-6-26 EXPOSITOR : Qco. Liddier Pérez Hincapié TÍTULO : " Reacción tricomponente A3 catalizada por complejos Au(I) y Au(III) con ligandos NHC hidrosolubles " FUENTE :   Trabajo de Investigación del expositor. DÍA, HORA y LUGAR : Lunes 8 de junio de 2026, 14:00 h, Aula de graduados y virtual. Modalidad virtual, Link : meet.google.com/wpi-ujuz-rok. Resumen : Se evaluó una familia de complejos de oro(I) y oro(III) con ligandos carbeno N-heterocíclicos (NHC) hidrosolubles en la reacción tricomponente A3 entre benzaldehído, piperidina y fenilacetileno, con el fin de analizar la influencia del estado de oxidación del metal y del entorno estérico del ligando sobre la actividad catalítica en medio acuoso. El impedimento estérico se cuantificó mediante el parámetro de volumen enterrado (%VBur). Los complejos de oro(III) mostraron una clara superioridad, con rendimientos del 96-98% en agua a 70 °C, frente al 20-41% de sus análogos de oro(I). Los complejos c...
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8º SEMINARIO QUÍMICA ORGÁNICA IQUIR 2026

SEMINARIO QUÍMICA ORGÁNICA 1-6-26 EXPOSITORA : Farm. Matías Borgogno TÍTULO : " The Discovery of RGH-706, a Highly Efficacious MCH1 Receptor Antagonist, for the Treatment of Obesity and Insatiable Hunger . " FUENTE :    J. Med. Chem. 2026, 69, 8, 8722–8738.  https://doi.org/10.1021/acs.jmedchem.5c02708 DÍA, HORA y LUGAR : Lunes 1 de junio de 2026, 14:00 h, Aula de graduados y virtual. Modalidad virtual, Link : meet.google.com/wpi-ujuz-rok. Resumen : The discovery and characterization of a novel 2,3,4,5-tetrahydro-1H-[1,4]diazepino[1,7-a]indole derivative MCH1 receptor antagonist (37) is disclosed. Starting from our previously investigated pyrazino[1,2-a]indole series and utilizing a scaffold hopping strategy, pyrimidine- and 1,4-diazepine-fused indole derivatives were designed and synthesized. Among these, only the prototype molecule containing the 2,3,4,5-tetrahydro-1H-[1,4]diazepino[1,7-a]indole scaffold emerged as a chemically stable and potent MCHR1 antagonist. Pre...
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