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9º SEMINARIO QUÍMICA ORGÁNICA IQUIR 2026

SEMINARIO QUÍMICA ORGÁNICA 8-6-26 EXPOSITOR : Qco. Liddier Pérez Hincapié TÍTULO : " Reacción tricomponente A3 catalizada por complejos Au(I) y Au(III) con ligandos NHC hidrosolubles " FUENTE :   Trabajo de Investigación del expositor. DÍA, HORA y LUGAR : Lunes 8 de junio de 2026, 14:00 h, Aula de graduados y virtual. Modalidad virtual, Link : meet.google.com/wpi-ujuz-rok. Resumen : Se evaluó una familia de complejos de oro(I) y oro(III) con ligandos carbeno N-heterocíclicos (NHC) hidrosolubles en la reacción tricomponente A3 entre benzaldehído, piperidina y fenilacetileno, con el fin de analizar la influencia del estado de oxidación del metal y del entorno estérico del ligando sobre la actividad catalítica en medio acuoso. El impedimento estérico se cuantificó mediante el parámetro de volumen enterrado (%VBur). Los complejos de oro(III) mostraron una clara superioridad, con rendimientos del 96-98% en agua a 70 °C, frente al 20-41% de sus análogos de oro(I). Los complejos c...
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8º SEMINARIO QUÍMICA ORGÁNICA IQUIR 2026

SEMINARIO QUÍMICA ORGÁNICA 1-6-26 EXPOSITORA : Farm. Matías Borgogno TÍTULO : " The Discovery of RGH-706, a Highly Efficacious MCH1 Receptor Antagonist, for the Treatment of Obesity and Insatiable Hunger . " FUENTE :    J. Med. Chem. 2026, 69, 8, 8722–8738.  https://doi.org/10.1021/acs.jmedchem.5c02708 DÍA, HORA y LUGAR : Lunes 1 de junio de 2026, 14:00 h, Aula de graduados y virtual. Modalidad virtual, Link : meet.google.com/wpi-ujuz-rok. Resumen : The discovery and characterization of a novel 2,3,4,5-tetrahydro-1H-[1,4]diazepino[1,7-a]indole derivative MCH1 receptor antagonist (37) is disclosed. Starting from our previously investigated pyrazino[1,2-a]indole series and utilizing a scaffold hopping strategy, pyrimidine- and 1,4-diazepine-fused indole derivatives were designed and synthesized. Among these, only the prototype molecule containing the 2,3,4,5-tetrahydro-1H-[1,4]diazepino[1,7-a]indole scaffold emerged as a chemically stable and potent MCHR1 antagonist. Pre...
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7º SEMINARIO QUÍMICA ORGÁNICA IQUIR 2026

SEMINARIO QUÍMICA ORGÁNICA 18-5-26 EXPOSITORA : Lic. Mauro Palumbo TÍTULO : " Studies Toward the Total Synthesis of Gliomasolide C ". FUENTE :  Sk Md Tarik Aziz, Subhash Ghosh. ChemistrySelect, 2026; 11: e0742 https://doi.org/10.1002/slct.202507426. DÍA, HORA y LUGAR : Lunes 18 de mayo de 2026, 14:00 h, Aula de graduados y virtual. Modalidad virtual, Link : meet.google.com/wpi-ujuz-rok. Resumen :   This article describes the synthetic studies of gliomasolide C utilizing D-mannitol as a chiral pool material. Julia–Kocienski olefina- tion and Noyori asymmetric reduction were employed to synthesize an advanced intermediate, from which two key precursors for ring-closing metathesis and intramolecular Horner–Wadsworth–Emmons olefination were prepared. Unfortunately, both ring- closing metathesis and Horner–Wadsworth–Emmons olefination were unsuccessful in constructing the desired 14-membered ( E )- α,β-macrolactone core.
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6º SEMINARIO QUÍMICA ORGÁNICA IQUIR 2026

SEMINARIO QUÍMICA ORGÁNICA 11-5-26 EXPOSITORA :  Dra.  Carina M. L. Delpiccolo TÍTULO :   " Idler Compounds: A Simple Protocol for Openly Sharing Fridge Contents for Cross-Screening ". FUENTE : Rebecka Isaksson, Eve M. Carter, Charlotte K. Hind, J. Mark Sutton, Hazel Rudgyard, Adam H. Roberts, Christopher W. Moon, Yinuo Wang, Todd Group Researchers, Sandra Codony, Antón L. Martínez, Joanna Bacon, and Matthew H. Todd J. Med. Chem. , 2026 , 69 , 2453-2461. DÍA, HORA y LUGAR : Lunes 11 de mayo de 2026, 14:00 h, Aula de graduados y virtual. Modalidad virtual, Link :  meet.google.com/wpi-ujuz-rok. Resumen : Academic drug discovery laboratories tend to accumulate collections of compounds with great potential value that merely reside in fridges and freezers. Cross screening these libraries against alternative targets holds significant potential for uncovering novel hits, but in the academic setting compound collections are rarely used, and shared, in this way. We present a...
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5º SEMINARIO QUÍMICA ORGÁNICA IQUIR 2026

SEMINARIO QUÍMICA ORGÁNICA 4-5-26 EXPOSITOR :  Qco.  Miguel R. Villarreal Parra TÍTULO :   " Quinazolin‐4(3H)‐One‐Based New Glitazones as Dual Inhibitors of α‐Glucosidase and Aldose Reductase: Comprehensive Approaches for Managing Diabetes Mellitus and Its Complications ". FUENTE : Tokalı, F.S., Demir, Y., Ateşoğlu, Ş., Tokalı, P. and Şenol, H. Archiv der Pharmazie, 2025, 358: e70033 https://doi.org/10.1002/ardp.70033 . DÍA, HORA y LUGAR : Lunes 4 de mayo de 2026, 14:00 h, Aula de graduados y virtual. Modalidad virtual, Link :  meet.google.com/wpi-ujuz-rok. Resumen :   A series of novel glitazones containing thiazolidine-2,4-dione and quinazolin-4(3H)-one moieties were synthesized to explore their potential as dual inhibitors of aldose reductase (ALR2) and α-glucosidase (α-Glu), two key enzymes involved in diabetes and its complications. In vitro assays revealed that compounds 8 (cyclohexyl substituted), 9 (phenethyl substituted), and 11 (phenyl substituted) e...
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4º SEMINARIO QUÍMICA ORGÁNICA IQUIR 2026

SEMINARIO QUÍMICA ORGÁNICA 27-4-26 EXPOSITOR :  Qco.  Arturo Mendoza Salgado TÍTULO :   " Total Synthesis of (±)-Cristaxenicin A: Construction of Nine-Membered Ring by Eschenmoser–Claisen/Cope Rearrangement Cascade ". FUENTE :   W.Kiuchi, Y.Tsunoda, K.Ishikura, K.Kato, J.Takino, T.Suzuki, K.Tanino, Angew. Chem. Int. Ed.  2026 , 65 , e24855. https://doi.org/10.1002/anie.202524855 . DÍA, HORA y LUGAR : Lunes 27 de abril de 2026, 14:00 h, Aula de graduados y virtual. Modalidad virtual, Link :  meet.google.com/wpi-ujuz-rok. Resumen :   Cristaxenicin A, a natural marine product with a skeleton consisting of a nine-membered carbocycle fused with a dihydropyran ring, displays strong antiprotozoal activity against Leishmania amazonensis and Trypanosoma congolense. The synthesis of cristaxenicin A is challenging because of its unique oxidation pattern at C11 and C20, the cis-cyclononane with a C5─C6 double bond, and the C1─C19 alkene moiety functionalized ...
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3º SEMINARIO QUÍMICA ORGÁNICA IQUIR 2026

SEMINARIO QUÍMICA ORGÁNICA 20-4-26 EXPOSITOR :  Dr. Ernesto G. Mata TÍTULO :   " Total Syntheses of Bryostatins ". FUENTE :   Guo, Q., Yang, Y., Zhang, H., Wang, D., Li, B., Jiang, D., ... & Song, Z. Angewandte Chemie , 2025 , 137 (14), e202423465. DÍA, HORA y LUGAR : Lunes 20 de abril de 2026, 14:00 h, Aula de graduados y virtual. Modalidad virtual, Link :  meet.google.com/wpi-ujuz-rok. Resumen : Bryostatin 1 34, produced by a bacterial symbiont of the marine bryozoan Begula neritina, has shown promise for the treatment of Alzheimer’s disease. This work reports the divergent total syntheses of bryostatins, obtaining 1.5 g of bryostatin 1 in the final three steps. Key methods include Ni-catalyzed reductive cross-coupling, flow-assisted light-induced radical addition, and a Prins cyclization for cis-Z selectivity. The syntheses require 20–22 linear steps (33–35 total) with overall yields of 3.3–4.5%.
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