SEMINARIOS AREA QUÍMICA ORGÁNICA FBIOYF/IQUIR

SEMINARIO QUÍMICA ORGÁNICA 27-4-26 EXPOSITOR :  Qco.  Arturo Mendoza Salgado TÍTULO :   " Total Synthesis of (±)-Cristaxenicin A: Construction of Nine-Membered Ring by Eschenmoser–Claisen/Cope Rearrangement Cascade ". FUENTE :   W.Kiuchi, Y.Tsunoda, K.Ishikura, K.Kato, J.Takino, T.Suzuki, K.Tanino, Angew. Chem. Int. Ed.  2026 , 65 , e24855. https://doi.org/10.1002/anie.202524855 . DÍA, HORA y LUGAR : Lunes 27 de abril de 2026, 14:00 h, Aula de graduados y virtual. Modalidad virtual, Link :  meet.google.com/wpi-ujuz-rok. Resumen :   Cristaxenicin A, a natural marine product with a skeleton consisting of a nine-membered carbocycle fused with a dihydropyran ring, displays strong antiprotozoal activity against Leishmania amazonensis and Trypanosoma congolense. The synthesis of cristaxenicin A is challenging because of its unique oxidation pattern at C11 and C20, the cis-cyclononane with a C5─C6 double bond, and the C1─C19 alkene moiety functionalized ...

SEMINARIO QUÍMICA ORGÁNICA 20-4-26 EXPOSITOR :  Dr. Ernesto G. Mata TÍTULO :   " Total Syntheses of Bryostatins ". FUENTE :   Guo, Q., Yang, Y., Zhang, H., Wang, D., Li, B., Jiang, D., ... & Song, Z. Angewandte Chemie , 2025 , 137 (14), e202423465. DÍA, HORA y LUGAR : Lunes 20 de abril de 2026, 14:00 h, Aula de graduados y virtual. Modalidad virtual, Link :  meet.google.com/wpi-ujuz-rok. Resumen : Bryostatin 1 34, produced by a bacterial symbiont of the marine bryozoan Begula neritina, has shown promise for the treatment of Alzheimer’s disease. This work reports the divergent total syntheses of bryostatins, obtaining 1.5 g of bryostatin 1 in the final three steps. Key methods include Ni-catalyzed reductive cross-coupling, flow-assisted light-induced radical addition, and a Prins cyclization for cis-Z selectivity. The syntheses require 20–22 linear steps (33–35 total) with overall yields of 3.3–4.5%.

SEMINARIO QUÍMICA ORGÁNICA 13-4-26 EXPOSITOR :  Lic. Darián Vazquez TÍTULO :   " Total syntheses of Tetrodotoxin and 9-epiTetrodotoxin ". FUENTE : Chen, P., Wang, J., Zhang, S. et al. Total syntheses of Tetrodotoxin and 9-epiTetrodotoxin. Nat Commun 15, 679 (2024). https://doi.org/10.1038/s41467-024-45037-0 . DÍA, HORA y LUGAR : Lunes 13 de abril de 2026, 14:00 h, híbrido. Modalidad presencial (Aula de graduados) y virtual, Link :  meet.google.com/wpi-ujuz-rok. Resumen : Tetrodotoxin and congeners are specific voltage-gated sodium channel blockers that exhibit remarkable anesthetic and analgesic effects. Here, we present a scalable asymmetric syntheses of Tetrodotoxin and 9-epiTetrodotoxin from the abundant chemical feedstock furfuryl alcohol. The optically pure cyclohexane skeleton is assembled via a stereoselective Diels-Alder reaction. The dense heteroatom substituents are established sequentially by a series of functional group interconversions on highly oxygenated ...

SEMINARIO QUÍMICA ORGÁNICA 6-4-26 EXPOSITOR : Lic. Lina V. López López TÍTULO :   " Late-Stage Functionalization of Amino Acids and Peptides ". FUENTE :  Trabajo de investigación de la presentadora. DÍA, HORA y LUGAR : Lunes 6 de abril de 2026, 14:00 h, Aula 12 y virtual. Modalidad virtual, Link :  meet.google.com/wpi-ujuz-rok. Resumen :  El seminario que se llevará a cabo presenta los resultados de la pasantía realizada el año pasado a través de una beca otorgada por la OPCW en Gif-Sur-Yvette (Francia), en el ICSN, bajo la supervisión del Dr. Philippe Dauban. El objetivo de este trabajo es establecer condiciones óptimas para la funcionalización selectiva de enlaces C–H en diversos aminoácidos, con el fin de extender estas metodologías a sistemas más complejos, como los péptidos.

SEMINARIO QUÍMICA ORGÁNICA 15-12-25 EXPOSITOR :   Dr. Tonino G. Adessi Cofré TÍTULO :   " Biomimetic synthesis of Sinularia meroterpenoids and photochemical reactivity of capillobenzopyranol ". FUENTE : French, S. A., Peralta, R. A., & George, J. H. (2025). Biomimetic synthesis of Sinularia meroterpenoids and photochemical reactivity of capillobenzopyranol. Organic & Biomolecular Chemistry. https://doi.org/10.1039/D5OB01430A DÍA, HORA y LUGAR : Lunes 15 de diciembre de 2025, 14:00 h, Aula 16 y virtual. Modalidad virtual, Link :  meet.google.com/wpi-ujuz-rok  ( Plataforma MEET GOOGLE) Resumen :  Motivated by a biosynthetic proposal which suggests a chemical relationship between capilloquinol and capillobenzopyranol, our studies report the first synthesis of their probable biogenetic precursors, furanoquinol and furanoquinone. A bioinspired cascade using an ortho-quinone methide intermediate derived from furanoquinone was attempted to construct the spiroc...

SEMINARIO QUÍMICA ORGÁNICA 17-11-25 EXPOSITOR :   Dra. Nadia  L. Martiren TÍTULO :   " Discovery of the Clinical Candidate S‑892216: A Second-Generation of SARS-CoV‑2 3CL Protease Inhibitor for Treating COVID-19 ". FUENTE : Yuto Unoh,* Keiichiro Hirai, Shota Uehara, Sho Kawashima, Haruaki Nobori, Jun Sato, Hiromitsu Shibayama, Akihiro Hori, Kenji Nakahara, Kana Kurahashi, Masayuki Takamatsu, Shiho Yamamoto, Qianhui Zhang, Miki Tanimura, Reiko Dodo, Yuki Maruyama, Hirofumi Sawa, Ryosuke Watari, Tetsuya Miyano, Teruhisa Kato, Takafumi Sato, and Yuki Tachibana "Discovery of the Clinical Candidate S‑892216: A Second-Generation of SARS-CoV‑2 3CL Protease Inhibitor for Treating COVID-19" J. Med. Chem. 2025, 68, 21099−21119. DOI: https://doi.org/10.1021/acs.jmedchem.5c00754 DÍA, HORA y LUGAR : Lunes 17 de noviembre de 2025, 14:00 h, Aula 18 y virtual. Modalidad virtual, Link :  meet.google.com/hjn-ygro-twf  ( Plataforma MEET GOOGLE) Resumen :  The coronavirus di...