SEMINARIOS AREA QUÍMICA ORGÁNICA FBIOYF/IQUIR

SEMINARIO QUÍMICA ORGÁNICA 7-9-26 EXPOSITORA : Dr. Guillermo R. Labadie TÍTULO : " Del espacio químico a la función biológica: estrategias Direct-to-Biology". Acelerando el descubrimiento de fármacos con flujos de trabajo integrados " FUENTE : Ariane F. Hübner , Fabian Barthels , ChemMedChem 2026 , 21 , e202501080. https://doi.org/10.1002/cmdc.202501080 . DÍA, HORA y LUGAR : Lunes 7 de septiembre de 2026, 14:00 h, Aula de graduados y virtual. Modalidad virtual, Link : meet.google.com/wpi-ujuz-rok. Resumen: Las estrategias Direct-to-Biology (D2B) proponen una nueva forma de integrar la síntesis con la evaluación biológica, acortando el ciclo DMTA (del inglés DMTA = Design → Make → Test → Analyze). En este seminario se presentarán los fundamentos y la evolución de las aproximaciones D2B, sus principales estrategias experimentales y tecnológicas, y algunos ejemplos recientes de su aplicación al descubrimiento de nuevos compuestos bioactivos. Se discutirán sus ventajas, ...

SEMINARIO QUÍMICA ORGÁNICA 31-8-26 EXPOSITORA :   Ing. Natalia A. Lenarduzzi D'Emilio TÍTULO : " Oxidation-Induced Scaffold Remodeling in Ainsliaea Disesquiterpenoids: Total Synthesis of Macrocephadiolide A " FUENTE : Gennaiou K.; Zografos A. L.; Org. Lett. 2026 , 28 , 4115−4119 . DÍA, HORA y LUGAR : Lunes 31 de agosto de 2026, 14:00 h, Aula de graduados y virtual. Modalidad virtual, Link : meet.google.com/wpi-ujuz-rok. Resumen : Late-stage oxidations extend terpenoid architectures beyond cyclase-defined boundaries, driving molecular complexity and functional diversity. Disesquiterpenoid biosynthesis illustrates this, as simple monomeric carbocycles evolve into sophisticated dimers through oxidative elaboration. Guided by this logic, we harnessed the oxidase phase of Ainsliaea congeners to generate natural and non-natural privileged scaffolds. A concise, five-step oxidative cascade from ainsliadimer A (3) delivers macrocephadiolide A (5), showcasing oxidation driven fr...

SEMINARIO QUÍMICA ORGÁNICA 24-8-26 EXPOSITORA : Lic. Josefina Huck TÍTULO : " A Practical Start-Up Guide for Synthetic Chemists to Implement Design of Experiments (DoE) " FUENTE : Wall, B. J.; Koeritz, M. T.; Stanley, L. M.; VanVeller, B. ACS Catal. 2025, 15 (11), 8885–8893 . DÍA, HORA y LUGAR : Lunes 24 de agosto de 2026, 14:00 h, Aula de graduados y virtual. Modalidad virtual, Link : meet.google.com/wpi-ujuz-rok. Resumen : Experimental design in the synthetic chemistry community primarily focuses on optimizing reaction conditions by modifying one variable at a time (OVAT). Design of Experiments (DoE) methodology, already commonplace in the chemical industry, captures optimal reaction conditions while shrinking the number of experiments required. Additionally, DoE can provide interaction effects between variables that are not captured in OVAT optimizations. Despite the cost- and time-saving benefits that DoE can provide, it has not been widely adopted by the academic co...

SEMINARIO QUÍMICA ORGÁNICA 10-8-26 EXPOSITOR : Dr. Iván Cortés TÍTULO :   "Nickel Catalysis via SH2 Homolytic Substitution: The Double Decarboxylative Cross-Coupling of Aliphatic Acids " FUENTE :     Artem V. Tsymbal, Lorenzo Delarue Bizzini, David W. C. MacMillan; Nickel Catalysis via SH2 Homolytic Substitution: The Double Decarboxylative Cross-Coupling of Aliphatic Acids. Journal American Chemical Society 23 November 2022; 144 (46): 21278–21286. https://doi.org/10.1021/jacs.2c08989 . DÍA, HORA y LUGAR : Lunes 10 de agosto de 2026, 14:00 h, Aula de graduados y virtual. Modalidad virtual, Link : meet.google.com/wpi-ujuz-rok. Resumen : Cross-coupling platforms are traditionally built around a sequence of closed-shell steps, such as oxidative addition, transmetalation, and reductive elimination. Herein, we describe a dual photo/nickel catalytic manifold that performs cross-coupling via a complementary sequence involving free radical generation, radical sorting via selecti...

SEMINARIO QUÍMICA ORGÁNICA 3-8-26 EXPOSITOR : Lic. Enzo Centurión TÍTULO : " Ladderanes: stepping up as nonclassical ortho-substituted benzene bioisosteres " FUENTE :    Adak, S. et al. Ladderanes: stepping up as nonclassical ortho-substituted benzene bioisosteres. J. Am. Chem. Soc. 148, 23078–23087 (2026). https://doi.org/10.1021/jacs.6c05064. DÍA, HORA y LUGAR : Lunes 3 de agosto de 2026, 14:00 h, Aula de graduados y virtual. Modalidad virtual, Link : meet.google.com/wpi-ujuz-rok. Resumen :  Modulating the physicochemical properties of small-molecule active pharmaceutical ingredients (APIs) is a vital component of the drug discovery process. In recent years, investigations of the synthesis and application of saturated isosteres for aromatic rings have been growing and have often been shown to improve the properties of an API in matched pairs analysis. While saturated isosteres for para-substituted aromatic rings are well-established, replacing ortho-substituted rings,...

SEMINARIO QUÍMICA ORGÁNICA 27-7-26 EXPOSITOR :  Lic. Matías Krivoy TÍTULO : " Photochemical permutation of thiazoles, isothiazoles and other azoles " FUENTE :   Roure, B., Alonso, M., Lonardi, G. et al. Photochemical permutation of thiazoles, isothiazoles and other azoles. Nature 637, 860–867 (2025). https://doi.org/10.1038/s41586-024-08342-8 . DÍA, HORA y LUGAR : Lunes 27 de julio de 2026, 14:00 h, Aula de graduados y virtual. Modalidad virtual, Link : meet.google.com/wpi-ujuz-rok. Resumen : Thiazoles and isothiazoles are privileged motifs in drug and agrochemical discovery. The synthesis of these derivatives is generally approached, designed and developed on a case-by-case basis. Sometimes, the lack of robust synthesis methods to a given target can pose considerable difficulties or even thwart the preparation of specific derivatives for further study. Here we report a conceptually different approach in which photochemical irradiation can be used to alter the structure o...