SEMINARIO QUÍMICA ORGÁNICA 1-6-26 EXPOSITORA : Farm. Matías Borgogno TÍTULO : " The Discovery of RGH-706, a Highly Efficacious MCH1 Receptor Antagonist, for the Treatment of Obesity and Insatiable Hunger . " FUENTE : J. Med. Chem. 2026, 69, 8, 8722–8738. https://doi.org/10.1021/acs.jmedchem.5c02708 DÍA, HORA y LUGAR : Lunes 1 de junio de 2026, 14:00 h, Aula de graduados y virtual. Modalidad virtual, Link : meet.google.com/wpi-ujuz-rok. Resumen : The discovery and characterization of a novel 2,3,4,5-tetrahydro-1H-[1,4]diazepino[1,7-a]indole derivative MCH1 receptor antagonist (37) is disclosed. Starting from our previously investigated pyrazino[1,2-a]indole series and utilizing a scaffold hopping strategy, pyrimidine- and 1,4-diazepine-fused indole derivatives were designed and synthesized. Among these, only the prototype molecule containing the 2,3,4,5-tetrahydro-1H-[1,4]diazepino[1,7-a]indole scaffold emerged as a chemically stable and potent MCHR1 antagonist. Pre...
SEMINARIO QUÍMICA ORGÁNICA 18-5-26 EXPOSITORA : Lic. Mauro Palumbo TÍTULO : " Studies Toward the Total Synthesis of Gliomasolide C ". FUENTE : Sk Md Tarik Aziz, Subhash Ghosh. ChemistrySelect, 2026; 11: e0742 https://doi.org/10.1002/slct.202507426. DÍA, HORA y LUGAR : Lunes 18 de mayo de 2026, 14:00 h, Aula de graduados y virtual. Modalidad virtual, Link : meet.google.com/wpi-ujuz-rok. Resumen : This article describes the synthetic studies of gliomasolide C utilizing D-mannitol as a chiral pool material. Julia–Kocienski olefina- tion and Noyori asymmetric reduction were employed to synthesize an advanced intermediate, from which two key precursors for ring-closing metathesis and intramolecular Horner–Wadsworth–Emmons olefination were prepared. Unfortunately, both ring- closing metathesis and Horner–Wadsworth–Emmons olefination were unsuccessful in constructing the desired 14-membered ( E )- α,β-macrolactone core.