SEMINARIOS AREA QUÍMICA ORGÁNICA FBIOYF/IQUIR

SEMINARIO QUÍMICA ORGÁNICA 3-8-26 EXPOSITOR : Lic. Enzo Centurión TÍTULO : " Ladderanes: stepping up as nonclassical ortho-substituted benzene bioisosteres " FUENTE :    Adak, S. et al. Ladderanes: stepping up as nonclassical ortho-substituted benzene bioisosteres. J. Am. Chem. Soc. 148, 23078–23087 (2026). https://doi.org/10.1021/jacs.6c05064. DÍA, HORA y LUGAR : Lunes 3 de agosto de 2026, 14:00 h, Aula de graduados y virtual. Modalidad virtual, Link : meet.google.com/wpi-ujuz-rok. Resumen :  Modulating the physicochemical properties of small-molecule active pharmaceutical ingredients (APIs) is a vital component of the drug discovery process. In recent years, investigations of the synthesis and application of saturated isosteres for aromatic rings have been growing and have often been shown to improve the properties of an API in matched pairs analysis. While saturated isosteres for para-substituted aromatic rings are well-established, replacing ortho-substituted rings,...

SEMINARIO QUÍMICA ORGÁNICA 27-7-26 EXPOSITOR :  Lic. Matías Krivoy TÍTULO : " Photochemical permutation of thiazoles, isothiazoles and other azoles " FUENTE :   Roure, B., Alonso, M., Lonardi, G. et al. Photochemical permutation of thiazoles, isothiazoles and other azoles. Nature 637, 860–867 (2025). https://doi.org/10.1038/s41586-024-08342-8 . DÍA, HORA y LUGAR : Lunes 27 de julio de 2026, 14:00 h, Aula de graduados y virtual. Modalidad virtual, Link : meet.google.com/wpi-ujuz-rok. Resumen : Thiazoles and isothiazoles are privileged motifs in drug and agrochemical discovery. The synthesis of these derivatives is generally approached, designed and developed on a case-by-case basis. Sometimes, the lack of robust synthesis methods to a given target can pose considerable difficulties or even thwart the preparation of specific derivatives for further study. Here we report a conceptually different approach in which photochemical irradiation can be used to alter the structure o...

SEMINARIO QUÍMICA ORGÁNICA 29-6-26 EXPOSITOR :  Qco. José Vaz Cardoso Machado TÍTULO : " Design, Synthesis, and Trypanosomicidal Evaluation of EugenolBased Azole Hybrids: Discovery of an In Vitro Active and Selective Compound. " FUENTE :   Qco.  José Vaz Cardoso Machado et al. , ACS Omega 2025 , 10 , 36, 41958–41974. DÍA, HORA y LUGAR : Lunes 29 de junio de 2026, 14:00 h, Aula de graduados y virtual. Modalidad virtual, Link : meet.google.com/wpi-ujuz-rok. Resumen :  Chagas disease, caused by Trypanosoma cruzi, remains a major public health concern in Latin America and beyond, with limited treatment options and high morbidity in chronic stages. Currently, benznidazole remains the first-line therapy for Chagas disease but exhibits considerable limitations, including dose-dependent toxicity and poor efficacy in long-term infections. In response to the pressing need for safer and more effective therapies, this study reports the design, synthesis, and biological evaluati...

SEMINARIO QUÍMICA ORGÁNICA 8-6-26 EXPOSITOR : Qco. Liddier Pérez Hincapié TÍTULO : " Reacción tricomponente A3 catalizada por complejos Au(I) y Au(III) con ligandos NHC hidrosolubles " FUENTE :   Trabajo de Investigación del expositor. DÍA, HORA y LUGAR : Lunes 8 de junio de 2026, 14:00 h, Aula de graduados y virtual. Modalidad virtual, Link : meet.google.com/wpi-ujuz-rok. Resumen : Se evaluó una familia de complejos de oro(I) y oro(III) con ligandos carbeno N-heterocíclicos (NHC) hidrosolubles en la reacción tricomponente A3 entre benzaldehído, piperidina y fenilacetileno, con el fin de analizar la influencia del estado de oxidación del metal y del entorno estérico del ligando sobre la actividad catalítica en medio acuoso. El impedimento estérico se cuantificó mediante el parámetro de volumen enterrado (%VBur). Los complejos de oro(III) mostraron una clara superioridad, con rendimientos del 96-98% en agua a 70 °C, frente al 20-41% de sus análogos de oro(I). Los complejos c...

SEMINARIO QUÍMICA ORGÁNICA 1-6-26 EXPOSITORA : Farm. Matías Borgogno TÍTULO : " The Discovery of RGH-706, a Highly Efficacious MCH1 Receptor Antagonist, for the Treatment of Obesity and Insatiable Hunger . " FUENTE :    J. Med. Chem. 2026, 69, 8, 8722–8738.  https://doi.org/10.1021/acs.jmedchem.5c02708 DÍA, HORA y LUGAR : Lunes 1 de junio de 2026, 14:00 h, Aula de graduados y virtual. Modalidad virtual, Link : meet.google.com/wpi-ujuz-rok. Resumen : The discovery and characterization of a novel 2,3,4,5-tetrahydro-1H-[1,4]diazepino[1,7-a]indole derivative MCH1 receptor antagonist (37) is disclosed. Starting from our previously investigated pyrazino[1,2-a]indole series and utilizing a scaffold hopping strategy, pyrimidine- and 1,4-diazepine-fused indole derivatives were designed and synthesized. Among these, only the prototype molecule containing the 2,3,4,5-tetrahydro-1H-[1,4]diazepino[1,7-a]indole scaffold emerged as a chemically stable and potent MCHR1 antagonist. Pre...

SEMINARIO QUÍMICA ORGÁNICA 18-5-26 EXPOSITORA : Lic. Mauro Palumbo TÍTULO : " Studies Toward the Total Synthesis of Gliomasolide C ". FUENTE :  Sk Md Tarik Aziz, Subhash Ghosh. ChemistrySelect, 2026; 11: e0742 https://doi.org/10.1002/slct.202507426. DÍA, HORA y LUGAR : Lunes 18 de mayo de 2026, 14:00 h, Aula de graduados y virtual. Modalidad virtual, Link : meet.google.com/wpi-ujuz-rok. Resumen :   This article describes the synthetic studies of gliomasolide C utilizing D-mannitol as a chiral pool material. Julia–Kocienski olefina- tion and Noyori asymmetric reduction were employed to synthesize an advanced intermediate, from which two key precursors for ring-closing metathesis and intramolecular Horner–Wadsworth–Emmons olefination were prepared. Unfortunately, both ring- closing metathesis and Horner–Wadsworth–Emmons olefination were unsuccessful in constructing the desired 14-membered ( E )- α,β-macrolactone core.