SEMINARIO QUÍMICA ORGÁNICA 27-7-26 EXPOSITOR : Lic. Matías Krivoy TÍTULO : " Photochemical permutation of thiazoles, isothiazoles and other azoles " FUENTE : Roure, B., Alonso, M., Lonardi, G. et al. Photochemical permutation of thiazoles, isothiazoles and other azoles. Nature 637, 860–867 (2025). https://doi.org/10.1038/s41586-024-08342-8 . DÍA, HORA y LUGAR : Lunes 27 de julio de 2026, 14:00 h, Aula de graduados y virtual. Modalidad virtual, Link : meet.google.com/wpi-ujuz-rok. Resumen : Thiazoles and isothiazoles are privileged motifs in drug and agrochemical discovery. The synthesis of these derivatives is generally approached, designed and developed on a case-by-case basis. Sometimes, the lack of robust synthesis methods to a given target can pose considerable difficulties or even thwart the preparation of specific derivatives for further study. Here we report a conceptually different approach in which photochemical irradiation can be used to alter the structure o...
SEMINARIO QUÍMICA ORGÁNICA 29-6-26 EXPOSITOR : Qco. José Vaz Cardoso Machado TÍTULO : " Design, Synthesis, and Trypanosomicidal Evaluation of EugenolBased Azole Hybrids: Discovery of an In Vitro Active and Selective Compound. " FUENTE : Qco. José Vaz Cardoso Machado et al. , ACS Omega 2025 , 10 , 36, 41958–41974. DÍA, HORA y LUGAR : Lunes 29 de junio de 2026, 14:00 h, Aula de graduados y virtual. Modalidad virtual, Link : meet.google.com/wpi-ujuz-rok. Resumen : Chagas disease, caused by Trypanosoma cruzi, remains a major public health concern in Latin America and beyond, with limited treatment options and high morbidity in chronic stages. Currently, benznidazole remains the first-line therapy for Chagas disease but exhibits considerable limitations, including dose-dependent toxicity and poor efficacy in long-term infections. In response to the pressing need for safer and more effective therapies, this study reports the design, synthesis, and biological evaluati...