7º SEMINARIO QUÍMICA ORGÁNICA IQUIR 2026

SEMINARIO QUÍMICA ORGÁNICA 18-5-26

EXPOSITORA: Lic. Mauro Palumbo

TÍTULO: "Studies Toward the Total Synthesis of Gliomasolide C".

FUENTE: Sk Md Tarik Aziz, Subhash Ghosh. ChemistrySelect, 2026; 11: e0742 https://doi.org/10.1002/slct.202507426.

DÍA, HORA y LUGAR: Lunes 18 de mayo de 2026, 14:00 h, Aula de graduados y virtual.

Modalidad virtual, Link: meet.google.com/wpi-ujuz-rok.

Resumen: This article describes the synthetic studies of gliomasolide C utilizing D-mannitol as a chiral pool material. Julia–Kocienski olefina- tion and Noyori asymmetric reduction were employed to synthesize an advanced intermediate, from which two key precursors for ring-closing metathesis and intramolecular Horner–Wadsworth–Emmons olefination were prepared. Unfortunately, both ring- closing metathesis and Horner–Wadsworth–Emmons olefination were unsuccessful in constructing the desired 14-membered (E)- α,β-macrolactone core.