SEMINARIOS AREA QUÍMICA ORGÁNICA FBIOYF/IQUIR

SEMINARIO QUÍMICA ORGÁNICA 3-8-26 EXPOSITOR : Lic. Enzo Centurión TÍTULO : " Ladderanes: stepping up as nonclassical ortho-substituted benzene bioisosteres " FUENTE :    Adak, S. et al. Ladderanes: stepping up as nonclassical ortho-substituted benzene bioisosteres. J. Am. Chem. Soc. 148, 23078–23087 (2026). https://doi.org/10.1021/jacs.6c05064. DÍA, HORA y LUGAR : Lunes 3 de agosto de 2026, 14:00 h, Aula de graduados y virtual. Modalidad virtual, Link : meet.google.com/wpi-ujuz-rok. Resumen :  Modulating the physicochemical properties of small-molecule active pharmaceutical ingredients (APIs) is a vital component of the drug discovery process. In recent years, investigations of the synthesis and application of saturated isosteres for aromatic rings have been growing and have often been shown to improve the properties of an API in matched pairs analysis. While saturated isosteres for para-substituted aromatic rings are well-established, replacing ortho-substituted rings,...

SEMINARIO QUÍMICA ORGÁNICA 27-7-26 EXPOSITOR :  Lic. Matías Krivoy TÍTULO : " Photochemical permutation of thiazoles, isothiazoles and other azoles " FUENTE :   Roure, B., Alonso, M., Lonardi, G. et al. Photochemical permutation of thiazoles, isothiazoles and other azoles. Nature 637, 860–867 (2025). https://doi.org/10.1038/s41586-024-08342-8 . DÍA, HORA y LUGAR : Lunes 27 de julio de 2026, 14:00 h, Aula de graduados y virtual. Modalidad virtual, Link : meet.google.com/wpi-ujuz-rok. Resumen : Thiazoles and isothiazoles are privileged motifs in drug and agrochemical discovery. The synthesis of these derivatives is generally approached, designed and developed on a case-by-case basis. Sometimes, the lack of robust synthesis methods to a given target can pose considerable difficulties or even thwart the preparation of specific derivatives for further study. Here we report a conceptually different approach in which photochemical irradiation can be used to alter the structure o...