SEMINARIOS AREA QUÍMICA ORGÁNICA FBIOYF/IQUIR

SEMINARIO QUÍMICA ORGÁNICA 4-5-26 EXPOSITOR :  Qco.  Miguel R. Villarreal Parra TÍTULO :   " Quinazolin‐4(3H)‐One‐Based New Glitazones as Dual Inhibitors of α‐Glucosidase and Aldose Reductase: Comprehensive Approaches for Managing Diabetes Mellitus and Its Complications ". FUENTE : Tokalı, F.S., Demir, Y., Ateşoğlu, Ş., Tokalı, P. and Şenol, H. Archiv der Pharmazie, 2025, 358: e70033 https://doi.org/10.1002/ardp.70033 . DÍA, HORA y LUGAR : Lunes 4 de mayo de 2026, 14:00 h, Aula de graduados y virtual. Modalidad virtual, Link :  meet.google.com/wpi-ujuz-rok. Resumen :   A series of novel glitazones containing thiazolidine-2,4-dione and quinazolin-4(3H)-one moieties were synthesized to explore their potential as dual inhibitors of aldose reductase (ALR2) and α-glucosidase (α-Glu), two key enzymes involved in diabetes and its complications. In vitro assays revealed that compounds 8 (cyclohexyl substituted), 9 (phenethyl substituted), and 11 (phenyl substituted) e...

SEMINARIO QUÍMICA ORGÁNICA 27-4-26 EXPOSITOR :  Qco.  Arturo Mendoza Salgado TÍTULO :   " Total Synthesis of (±)-Cristaxenicin A: Construction of Nine-Membered Ring by Eschenmoser–Claisen/Cope Rearrangement Cascade ". FUENTE :   W.Kiuchi, Y.Tsunoda, K.Ishikura, K.Kato, J.Takino, T.Suzuki, K.Tanino, Angew. Chem. Int. Ed.  2026 , 65 , e24855. https://doi.org/10.1002/anie.202524855 . DÍA, HORA y LUGAR : Lunes 27 de abril de 2026, 14:00 h, Aula de graduados y virtual. Modalidad virtual, Link :  meet.google.com/wpi-ujuz-rok. Resumen :   Cristaxenicin A, a natural marine product with a skeleton consisting of a nine-membered carbocycle fused with a dihydropyran ring, displays strong antiprotozoal activity against Leishmania amazonensis and Trypanosoma congolense. The synthesis of cristaxenicin A is challenging because of its unique oxidation pattern at C11 and C20, the cis-cyclononane with a C5─C6 double bond, and the C1─C19 alkene moiety functionalized ...

SEMINARIO QUÍMICA ORGÁNICA 20-4-26 EXPOSITOR :  Dr. Ernesto G. Mata TÍTULO :   " Total Syntheses of Bryostatins ". FUENTE :   Guo, Q., Yang, Y., Zhang, H., Wang, D., Li, B., Jiang, D., ... & Song, Z. Angewandte Chemie , 2025 , 137 (14), e202423465. DÍA, HORA y LUGAR : Lunes 20 de abril de 2026, 14:00 h, Aula de graduados y virtual. Modalidad virtual, Link :  meet.google.com/wpi-ujuz-rok. Resumen : Bryostatin 1 34, produced by a bacterial symbiont of the marine bryozoan Begula neritina, has shown promise for the treatment of Alzheimer’s disease. This work reports the divergent total syntheses of bryostatins, obtaining 1.5 g of bryostatin 1 in the final three steps. Key methods include Ni-catalyzed reductive cross-coupling, flow-assisted light-induced radical addition, and a Prins cyclization for cis-Z selectivity. The syntheses require 20–22 linear steps (33–35 total) with overall yields of 3.3–4.5%.

SEMINARIO QUÍMICA ORGÁNICA 13-4-26 EXPOSITOR :  Lic. Darián Vazquez TÍTULO :   " Total syntheses of Tetrodotoxin and 9-epiTetrodotoxin ". FUENTE : Chen, P., Wang, J., Zhang, S. et al. Total syntheses of Tetrodotoxin and 9-epiTetrodotoxin. Nat Commun 15, 679 (2024). https://doi.org/10.1038/s41467-024-45037-0 . DÍA, HORA y LUGAR : Lunes 13 de abril de 2026, 14:00 h, híbrido. Modalidad presencial (Aula de graduados) y virtual, Link :  meet.google.com/wpi-ujuz-rok. Resumen : Tetrodotoxin and congeners are specific voltage-gated sodium channel blockers that exhibit remarkable anesthetic and analgesic effects. Here, we present a scalable asymmetric syntheses of Tetrodotoxin and 9-epiTetrodotoxin from the abundant chemical feedstock furfuryl alcohol. The optically pure cyclohexane skeleton is assembled via a stereoselective Diels-Alder reaction. The dense heteroatom substituents are established sequentially by a series of functional group interconversions on highly oxygenated ...