SEMINARIOS AREA QUÍMICA ORGÁNICA FBIOYF/IQUIR

SEMINARIO QUÍMICA ORGÁNICA 30-11-20 EXPOSITOR : Prof. Dr. Ernesto G. Mata TÍTULO : "Time Economy in Total Synthesis" FUENTE :   Hayashi, Y. J. Org. Chem. 2020 , ASAP, https://doi.org/10.1021/acs.joc.0c01581 , y referencias allí citadas. DÍA, HORA y LUGAR : Lunes 30 de noviembre de 2020, 18:00 h, Plataforma MEET GOOGLE. Link :  meet.google.com/bfh-poxv-bso RESUMEN :   It is often said that “time is money”. This is certainly true in a multistep synthesis when a high-valued product or set of products is needed urgently. Fulfilling this need requires the sensible balancing of atom economy, step economy, and redox economy with the time taken to make the product. In this age of flu-based pandemics, the need for rapid provision of effective therapeutic agents makes the importance of “time economy” particularly clear. In this work, the importance of time economy in total synthesis is described, as well as the general considerations underlining the timely production of desired mo...

SEMINARIO QUÍMICA ORGÁNICA 16-11-20 EXPOSITOR : Lic. Florencia Cámpora TÍTULO : " Síntesis Electro-orgánica" FUENTE :  (a)  Cian Kingston, Maximilian D. Palkowitz, Yusuke Takahira, Julien C. Vantourout, Byron K. Peters, Yu Kawamata, and Phil S. Baran, Acc. Chem. Res.   2020 ,  53 , 72-83. (b)  Dennis Pollok and Siegfried R. Waldvogel, Chem. Sci. , 2020 , Advance Article.   DÍA, HORA y LUGAR : Lunes 16 de noviembre de 2020, 18:00 h, Plataforma MEET GOOGLE. Link :  meet.google.com/bfh-poxv-bso RESUMEN :   The fierce limitation of fossil fuels and finite ressources influence the scientific community reconsidering chemical synthesis and establishing sustainable techniques. Several auspicious methods have emerged, whereas electro-organic conversions attract particular attention from the international academia and industry as environmentally begnin and cost-effective technique. An easy application, precise control, and safe conversion of substrates with...

SEMINARIO QUÍMICA ORGÁNICA 09-11-20 EXPOSITOR : Lic. Renzo Carlucci TÍTULO : " Interacciones moleculares de compuestos derivados de pirazinas en proteinas" FUENTE :   Juhás, M., & Zitko, J. Molecular Interactions of Pyrazine-Based Compounds to Proteins. Journal of Medicinal Chemistry 2020 , 63 , 8901-8916 . DÍA, HORA y LUGAR : Lunes 9 de noviembre de 2020, 18:00 h, Plataforma MEET GOOGLE. Link :  meet.google.com/bfh-poxv-bso RESUMEN :   Pyrazine-based compounds are of great importance in medicinal chemistry. Due to their heteroaromatic nature, they uniquely combine properties of heteroatoms (polar interactions) with the properties of aromatic moieties (nonpolar interactions). This review summarizes results of a systematic analysis of RCSB PDB database focused on important binding interactions of pyrazine-based ligands cocrystallized in protein targets. The most frequent interaction of pyrazine was hydrogen bond to pyrazine nitrogen atom as an acceptor, followed by we...