SEMINARIO QUÍMICA ORGÁNICA 05-04-21 EXPOSITOR : Lic. Federico Dezotti TÍTULO : " Evolution of a Strategy for the Enantioselective Synthesis of (−)-Cajanusine " FUENTE : Renyu Guo, Brittany P. Witherspoon, and M. Kevin Brown J. Am. Chem. Soc. 2020 , 142 , 5002–5006. https://pubs.acs.org/doi/10.1021/jacs.0c00359 DÍA, HORA y LUGAR : Lunes 5 de abril de 2021, 18:00 h, Plataforma MEET GOOGLE. Link : meet.google.com/bfh-poxv-bso RESUMEN : The first enantioselective synthesis of (−)-cajanusine is presented. Key features of the route include a rapid synthesis of the [4.2.0]bicyclooctane core by an enantioselective isomerization/stereoselective [2+2]-cycloaddition strategy as well as prominent use of catalytic methods for bond construction. The evolution of the approach is also presented that highlights unexpected roadblocks and how novel solutions were developed.