SEMINARIOS AREA QUÍMICA ORGÁNICA FBIOYF/IQUIR

SEMINARIO QUÍMICA ORGÁNICA 31-05-21 EXPOSITOR : Qco.  Liddier Pérez Hincapié TÍTULO :  " Synthesis of 1,4,6-Tricarbonyl Compounds via Regioselective Gold(I)-Catalyzed Alkyne Hydration and Their Application in the Synthesis of α‑Arylidene-butyrolactones " FUENTE :   Samia R. Lima, Fernando Coelho. ACS Omega 2020 , 5 , 8032−8045. https://dx.doi.org/10.1021/acsomega.0c00101 DÍA, HORA y LUGAR : Lunes 31 de mayo de 2021, 18:00 h, Plataforma MEET GOOGLE. Link :  meet.google.com/bfh-poxv-bso RESUMEN : We report a direct, straightforward, and regioselective hydration of 1,4-enynes designed from Morita−Baylis−Hillman adducts. Under smooth conditions and short reaction times, gold-catalyzed hydration of internal alkynes provides synthetically useful ketones as single regioisomers in yields higher than 90%. The synthetic usefulness of this protocol was demonstrated by the conversion of selected ketones into biologically valuable α-alkylidene-γ-lactones upon reduction with sod...

SEMINARIO QUÍMICA ORGÁNICA 17-05-21 EXPOSITOR : Lic. Gabriel Di Gresia TÍTULO :  " Synthesis and evaluation of 3'-fluorinated 7-deazapurine nucleosides as antikinetoplastid agents " FUENTE :   Bouton J., Furquim d’Almeida A., Maes L. , Caljon G., Van Calenbergh S., Hulpia F. European Journal of Medicinal Chemistry 216 ( 2021 ) 113290 . https://doi.org/10.1016/j.ejmech.2021.113290 DÍA, HORA y LUGAR : Lunes 17 de mayo de 2021, 18:00 h, Plataforma MEET GOOGLE. Link :  meet.google.com/bfh-poxv-bso RESUMEN :   Kinetoplastid parasites are the causative agents of neglected tropical diseases with an unmet medical need. These parasites are unable to synthesize the purine ring de novo, and therefore rely on purine salvage to meet their purine demand. Evaluating purine nucleoside analogs is therefore an attractive strategy to identify antikinetoplastid agents. Several anti-Trypanosoma cruzi and anti-Trypanosoma brucei  7-deazapurine nucleosides were previously discovered,...