SEMINARIOS AREA QUÍMICA ORGÁNICA FBIOYF/IQUIR

SEMINARIO QUÍMICA ORGÁNICA 02-08-21 EXPOSITOR :   Dra.  María Betina Comba TÍTULO :   " Efficient synthesis of antiviral agent uprifosbuvir enabled by new synthetic methods ". FUENTE :   Artis Klapars, John Y. L. Chung, John Limanto,a Ralph Calabria,a Louis-Charles Campeau, a Kevin R. Campos, Wenyong Chen, Stephen M. Dalby, Tyler A. Davis, Daniel A. DiRocco, Alan M. Hyde,a Amude M. Kassim, Mona Utne Larsen, Guiquan Liu, Peter E. Maligres, Aaron Moment, Feng Peng, Rebecca T. Ruck, Michael Shevlin, Bryon L. Simmons, Zhiguo Jake Song, Lushi Tan, Timothy J. Wrighta and Susan L. Zultanski. Chem. Sci., 2021 ,  12 , 9031-9036. DÍA, HORA y LUGAR : Lunes 2 de agosto de 2021, 18:00 h, Plataforma MEET GOOGLE. Link :  meet.google.com/bfh-poxv-bso RESUMEN :   An efficient route to the HCV antiviral agent uprifosbuvir was developed in 5 steps from readily available uridine in 50% overall yield. This concise synthesis was achieved by development of several synthetic...

SEMINARIO QUÍMICA ORGÁNICA 26-07-21 EXPOSITOR :   Dra.  María Sol Ballari TÍTULO :   " Rational design of a photoswitchable DNA glue enabling high regulatory function and supramolecular chirality transfer ". FUENTE : Simeth, N. A.; Kobayashi, S.; Kobauri, P.; Crespi, S.; Szymanski, W.; Nakatani, K.; Dohno, C.; Feringa, B. L. Chem. Sci. 2021 , 12 , 9207–9220. DÍA, HORA y LUGAR : Lunes 26 de julio de 2021, 18:00 h, Plataforma MEET GOOGLE. Link :  meet.google.com/bfh-poxv-bso RESUMEN :   Short, complementary DNA single strands with mismatched base pairs cannot undergo spontaneous formation of duplex DNA (dsDNA). Mismatch binding ligands (MBLs) can compensate this effect, inducing the formation of the double helix and thereby acting as a molecular glue. Here, we present the rational design of photoswitchable MBLs that allow for reversible dsDNA assembly by light. Careful choice of the azobenzene core structure results in excellent band separation of the E and Z iso...