SEMINARIO QUÍMICA ORGÁNICA 04-04-22 EXPOSITOR : Dr. Didier Farley Vargas Vargas TÍTULO : " Total Synthesis of the Acetyl CoA Carboxylase Inhibitor Soraphen A: Asymmetric Tsuji Reduction Enables Successive Olefin Metathesis " . FUENTE : Schempp, T. T. and Krische, M. J. J. Am. Chem. Soc. 2022 , 144 , 1016–1022. DÍA, HORA y LUGAR : Lunes 4 de abril de 2022, 18:00 h, Plataforma MEET GOOGLE. Link : meet.google.com/bfh-poxv-bso RESUMEN : The total synthesis of soraphen A, a myxobacterial metabolite and inhibitor of acetyl CoA carboxylase, was completed in 11 steps (longest linear sequence), less than half the steps previously required. Seven metal-catalyzed processes were deployed to unlock step-economy (comprising five asymmetric processes and four C–C bond formations). The present route does not utilize chiral auxiliaries, and four of five C–C bond formations exploit non-premetalated partners. To maximize convergency, an asymmetric Tsuji reducti...