SEMINARIO QUÍMICA ORGÁNICA 13-06-22 EXPOSITOR : Lic. Gabriel Di Gresia TÍTULO : " Self-Masked Aldehyde Inhibitors: A Novel Strategy for Inhibiting Cysteine Proteases " . FUENTE : Linfeng Li, Bala C. Chenna, Kai S. Yang, Taylor R. Cole, Zachary T. Goodall, Miriam Giardini, Zahra Moghadamchargari, Elizabeth A. Hernandez, Jana Gomez, Claudia M. Calvet, Jean A. Bernatchez, Drake M. Mellott, Jiyun Zhu, Andrew Rademacher, Diane Thomas, Lauren R. Blankenship, Aleksandra Drelich, Arthur Laganowsky, Chien-Te K. Tseng, Wenshe R. Liu, A. Joshua Wand, Jorge Cruz-Reyes, Jair L. Siqueira-Neto, and Thomas D. Meek* J. Med. Chem. 2021 , 64 , 11267–11287. DÍA, HORA y LUGAR : Lunes 13 de junio de 2022, 14:00 h. Plataforma MEET GOOGLE. Link : meet.google.com/bfh-poxv-bso RESUMEN : Cysteine proteases comprise an important class of drug targets, especially for infectious diseases such as Chagas disease (cruzain) and COVID-19 (3CL protease, cathepsin L). Peptide ald...