SEMINARIO QUÍMICA ORGÁNICA 5-12-22 EXPOSITOR : Qco. Liddier Pérez Hincapié TÍTULO : " Total Synthesis of Darobactin A " . FUENTE : Marko Nesic, David B. Ryffel, Jonathan Maturano, Michael Shevlin, Scott R. Pollack, Donald R. Gauthier Jr., Pablo Trigo-Mouriño, Li-Kang Zhang, Danielle M. Schultz, Jamie M. McCabe Dunn, Louis-Charles Campeau, Niki R. Patel*, David A. Petrone*, and David Sarlah* J. Am. Chem. Soc. 2022 , 144 , 14026–14030 . DÍA, HORA y LUGAR : Lunes 5 de diciembre de 2022, 15:00 h, Aula 16 Modalidad virtual, Link : meet.google.com/hjn-ygro-twf ( Plataforma MEET GOOGLE) RESUMEN : The collaborative total synthesis of darobactin A, a recently isolated antibiotic that selectively targets Gram-negative bacteria, has been accomplished in a convergent fashion with a longest linear sequence of 16 steps from d-Garner’s aldehyde and l-serine. Scalable routes toward three non-canonical amino acids were developed to enable the synthesis. The c...