SEMINARIO QUÍMICA ORGÁNICA 03-04-23 EXPOSITOR : Qco. Miguel Ricardo Villarreal TÍTULO : " Chemical Optimization of CBL0137 for Human African Trypanosomiasis Lead Drug Discovery " . FUENTE : Baljinder Singh, Amrita Sharma, Naresh Gunaganti, Mitch Rivers, Pradip K. Gadekar, Brady Greene, Michael Chichioco, Carlos E. Sanz-Rodriguez, Courtney Fu, Catherine LeBlanc, Erin Burchfield, Nyle Sharif, Benjamin Hoffman, Gaurav Kumar, Andrei Purmal, Kojo Mensa-Wilmot, and Michael P. Pollastri, Journal of Medicinal Chemistry 2023 66 (3), 1972-1989. DOI: 10.1021/acs.jmedchem.2c01767 DÍA, HORA y LUGAR : Lunes 3 de abril de 2023, 14:00 h, Aula 18 Modalidad virtual, Link : meet.google.com/hjn-ygro-twf ( Plataforma MEET GOOGLE) RESUMEN : The carbazole CBL0137 (1) is a lead for drug development against human African trypanosomiasis (HAT), a disease caused by Trypanosoma brucei. To advance 1 as a candidate drug, we synthesized new analogs that were e...