SEMINARIOS AREA QUÍMICA ORGÁNICA FBIOYF/IQUIR

SEMINARIO QUÍMICA ORGÁNICA 24-04-23 EXPOSITOR : Lic. Tomás A. Dómina TÍTULO :   " Stereoselective Tandem Synthesis of Pyrrolidine Derivatives under Gold Catalysis: An Asymmetric Synthesis of (−)-Lepadiformine A " . FUENTE :  Atsushi Yoshimura, Ryohei Hanzawa, and Haruhiko Fuwa Org. Lett. 2022 , 24 , 6237−6241. https://doi.org/10.1021/acs.orglett.2c02007 DÍA, HORA y LUGAR : Lunes 24 de abril de 2023, 14:00 h, Aula 18 y virtual Modalidad virtual, Link :  meet.google.com/hjn-ygro-twf  ( Plataforma MEET GOOGLE) RESUMEN :   A Au-catalyzed tandem alkyne hydroamination/iminium ion formation/allylation reaction was developed for expedient access to pyrrolidine derivatives bearing a tetrasubstituted carbon stereocenter. The tandem reaction was successfully applied to a 12-step asymmetric synthesis of (−)-lepadiformine A, a marine cytotoxic tricyclic alkaloid.

SEMINARIO QUÍMICA ORGÁNICA 17-04-23 EXPOSITOR : Dra. Agustina La Venia TÍTULO :   " Tetrazine evolution in bioorthognal IEDDA reactions " . FUENTE :  J. Am. Chem. Soc. 2022 , 144 , 1647 Chem. Soc. Rev.   2017 , 46 , 4895 Molecules 2021 , 26 , 1868 DÍA, HORA y LUGAR : Lunes 17 de abril de 2023, 12:50 h, Aula 1 y virtual Modalidad virtual, Link :  meet.google.com/hjn-ygro-twf  ( Plataforma MEET GOOGLE) RESUMEN :   The emerging inverse electron demand Diels–Alder (IEDDA) reaction stands out from other bioorthogonal reactions by virtue of its unmatchable kinetics, excellent orthogonality and biocompatibility. With the recent discovery of novel dienophiles and optimal tetrazine coupling partners, attention has now been turned to the use of IEDDA approaches in basic biology, imaging and therapeutics. An example of spatiotemporally controlled labeling and patterning of biomolecules in live cells through the catalytic activation of bioorthogonal chemistry with lig...

SEMINARIO QUÍMICA ORGÁNICA 10-04-23 EXPOSITOR : Lic. Lucas Passaglia TÍTULO :   " Control of stereogenic oxygen in a helically chiral oxonium ion " . FUENTE :  Smith, O., Popescu, M.V., Hindson, M.J., Paton, R.S, Burton, J.W., Smith M.D, Nature, 2023, 615, 430–435.  https://doi.org/10.1038/s41586-023-05719-z DÍA, HORA y LUGAR : Lunes 10 de abril de 2023, 14:00 h, Aula 18 Modalidad virtual, Link :  meet.google.com/hjn-ygro-twf  ( Plataforma MEET GOOGLE) RESUMEN :   The control of tetrahedral carbon stereocentres remains a focus of modern synthetic chemistry and is enabled by their configurational stability. By contrast, trisubstituted nitrogen, phosphorus and sulfur compounds undergo pyramidal inversion, a fundamental and well-recognized stereochemical phenomenon that is widely exploited 4 . However, the stereochemistry of oxonium ions—compounds bearing three substituents on a positively charged oxygen atom—is poorly developed and there are few applications ...