SEMINARIOS AREA QUÍMICA ORGÁNICA FBIOYF/IQUIR

SEMINARIO QUÍMICA ORGÁNICA 2-6-25 EXPOSITOR :  Dr. Ariel M. Sarotti TÍTULO :   " Toward Chiral Recognition by Design: Uncovering the Self-Enantioresolving Properties of Chiral Amine Derivatives " FUENTE : Anka Hagelschuer, Damián Padín, Vanda Dašková, Ben L. Feringa. J. Am. Chem. Soc. 2025, ASAP. https://doi.org/10.1021/jacs.5c01251 DÍA, HORA y LUGAR : Lunes 2 de junio de 2025, 14:00 h, Aula 18 y virtual. Modalidad virtual, Link :  meet.google.com/hjn-ygro-twf  ( Plataforma MEET GOOGLE) Resumen :  The study of chiral recognition phenomena is key for understanding biological processes, designing bioactive compounds, and for asymmetric catalysis and chiral analysis. In addition, phenomena related to the self-recognition of enantiomers are highly relevant in emergence-of-homochirality research and supramolecular chemistry. However, the design of molecules exhibiting chiral self-recognition remains challenging, and its observation is mainly based on serendipity. He...

SEMINARIO QUÍMICA ORGÁNICA 26-5-25 EXPOSITOR :  Lic. Enzo F. G. Centurión TÍTULO :   " De Novo Synthesis of Dihydrobenzofurans and Indolines and Its Application to a Modular, Asymmetric Synthesis of Beraprost " FUENTE :   Ze-Shu Wang et al .  J. Am. Chem. Soc. 2023 , 145 , 14124–14132.  https://doi.org/10.1021/jacs.3c04582 DÍA, HORA y LUGAR : Lunes 26 de mayo de 2025, 14:00 h, Aula 18 y virtual. Modalidad virtual, Link :  meet.google.com/hjn-ygro-twf  ( Plataforma MEET GOOGLE) Resumen : Dihydrobenzofurans and indolines are important constituents of pharmaceuticals. Herein, we describe a novel strategy for their construction in which the aromatic ring is created de novo through an inverse-electron demand Diels–Alder reaction and cheletropic extrusion sequence of a 2-halothiophene-1,1-dioxide with an enol ether/enamide, followed by aromatization. Unusually, the aromatization process proved to be highly challenging, but it was discovered that treatment o...

SEMINARIO QUÍMICA ORGÁNICA 19-5-25 EXPOSITOR :  Lic. Matías Krivoy TÍTULO :   " Synthesis and in vitro and in silico studies of 1H- and 2H-1,2,3-triazoles as antichagasic agents " FUENTE :   Thais B. Silva et al. Bioorganic Chemistry , 2021 , 116 , 105250. https://www.sciencedirect.com/science/article/pii/S0045206821006271 DÍA, HORA y LUGAR : Lunes 19 de mayo de 2025, 14:00 h, Aula 18 y virtual. Modalidad virtual, Link :  meet.google.com/hjn-ygro-twf  ( Plataforma MEET GOOGLE) Resumen :  1,2,3-triazole heterocycles stand out in medicinal chemistry for having great structural diversity and bioactivities. In this study, two series of triazoles were synthesized. One was obtained by the 1,3-dipolar cycloaddition reaction between ethyl cyanoacetate and several phenyl azides forming 1H-1,2,3-triazoles and the other by rearrangement of Dimroth forming and 2H-1,2,3-triazoles. Both series were shown to be active against the epimastigote form of Trypanosoma cruzi. Th...

SEMINARIO QUÍMICA ORGÁNICA 12-5-25 EXPOSITOR :  Dra. Agustina La Venia TÍTULO :   " Recent Progress and Prospects of Small Molecules for NLRP3 Inflammasome Inhibition " FUENTE :  Ying Chen, et al. Cell. Mol. Biol. Lett.  2023 ,  28 , 51 . Na Li, et al.  J. Med. Chem. 2023 , 66 ,   14447-14473. DÍA, HORA y LUGAR : Lunes 12 de mayo de 2025, 14:00 h, Aula 18 y virtual. Modalidad virtual, Link :  meet.google.com/hjn-ygro-twf  ( Plataforma MEET GOOGLE) Resumen : NLRP3 inflammasome is a multiprotein complex involved in host immune response which exerts various biological effects by mediating the maturation and secretion of IL-1β and IL-18and pyroptosis. However, its aberrant activation could cause amplification of inflammatory effects, thereby triggering a range of ailments, including Alzheimer’s disease, Parkinson’s disease, rheumatoid arthritis, gout, type 2 diabetes mellitus, and cancer. For the past few years, as an attractive anti-inflammato...