SEMINARIO QUÍMICA ORGÁNICA 4-8-25 EXPOSITOR : Ing. Natalia Lenarduzzi TÍTULO : " Asymmetric Total Synthesis of 4,9,10-Trihydroxyguaia-11(13)en-12,6-olide and Discovery of Its Anticancer Activity against Atypical Teratoid Rhabdoid Tumor ". FUENTE : Hyejin Lee, et al. ACS Cent. Sci. 2025 , 11 , 7, 1103–1110. https://doi.org/10.1021/acscentsci.5c00332 . DÍA, HORA y LUGAR : Lunes 4 de agosto de 2025, 14:00 h, Aula 18 y virtual. Modalidad virtual, Link : meet.google.com/hjn-ygro-twf ( Plataforma MEET GOOGLE) Resumen : The guaianolide family of sesquiterpene lactones is known for its distinctive structural features and diverse biological activities. 4,9,10-Trihydroxyguaia-11(13)en-12,6-olide, with an underdetermined absolute stereochemistry (1 or ent-1), is a newly identified 6,12-guaianolide isolated from the genus Anvillea garcinii. Motivated by the potential biological activity of the natural product, we pursue its stereoselective synthesis. Starting from...