SEMINARIO QUÍMICA ORGÁNICA 22-06-20
TÍTULO: "Divergent Total Synthesis of Chaetoglines C to F"
FUENTE: Shi,Y ; Xu,Z ; Tan, R, Lei, X. J. Org. Chem. 2019, 84, 8766-8770.
EXPOSITOR: Lic. Elida Thobokholt
DÍA, HORA y LUGAR: Lunes 22 de junio de 2020, 14 h, Plataforma MEET GOOGLE.
Link: meet.google.com/ksi-cypi-pif
RESUMEN:
The first total syntheses of chaetoglines C-F via a bioinspired and divergent synthetic strategy are reported. Chaetoglines C and D were obtained from the condensation of
hemiacetal and tryptophan methyl ester building blocks followed by functional group transformations. The synthesis of chaetogline E employed the diastereoselective Pictet-
Spengler reaction, and the tetrahydro-carboline skeleton was further utilized as a precursor for an oxidative aromatization reaction to introduce the β-carboline moiety of chaetogline F.
TÍTULO: "Divergent Total Synthesis of Chaetoglines C to F"
FUENTE: Shi,Y ; Xu,Z ; Tan, R, Lei, X. J. Org. Chem. 2019, 84, 8766-8770.
EXPOSITOR: Lic. Elida Thobokholt
DÍA, HORA y LUGAR: Lunes 22 de junio de 2020, 14 h, Plataforma MEET GOOGLE.
Link: meet.google.com/ksi-cypi-pif
RESUMEN:
The first total syntheses of chaetoglines C-F via a bioinspired and divergent synthetic strategy are reported. Chaetoglines C and D were obtained from the condensation of
hemiacetal and tryptophan methyl ester building blocks followed by functional group transformations. The synthesis of chaetogline E employed the diastereoselective Pictet-
Spengler reaction, and the tetrahydro-carboline skeleton was further utilized as a precursor for an oxidative aromatization reaction to introduce the β-carboline moiety of chaetogline F.
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