SEMINARIOS AREA QUÍMICA ORGÁNICA FBIOYF/IQUIR

SEMINARIO QUÍMICA ORGÁNICA 06-09-21 EXPOSITOR :  Dr. Sebastián O. Simonetti TÍTULO :  " Descarboxilación directa reversible de ácidos orgánicos estables  en solución de dimetilformamida " . FUENTE :   Kong, D., Moon, P. J., Lui, E. K., Bsharat, O. y Lundgren, R. J. Science 2020, 369, 557-561. DÍA, HORA y LUGAR : Lunes 6 de septiembre de 2021, 18:00 h, Plataforma MEET GOOGLE. Link :  meet.google.com/bfh-poxv-bso RESUMEN :  Muchos métodos sintéticos utilizan la liberación de CO2 como herramienta para la formación de nuevos enlaces. La reacción microscópicamente inversa, la carboxilación, se ha realizado utilizando condiciones diferentes a la descarboxilación. Lundgren et al. reportan que carboxilatos estables tales como ácido arilacético puede otorgar descarboxilación en solución de dimetilformamida. Mediante esta observación, pueden ser preparados ácidos carboxílicos isotópicamente enriquecidos simplemente sometiendo al ácido carboxílico en solución de solve...

SEMINARIO QUÍMICA ORGÁNICA 30-08-21 EXPOSITOR :  Lic. Caterina Permingeat Squizzato TÍTULO :  " Catalysis in Supramolecular Systems: the Case of Gel Phases " . FUENTE : Carla Rizzo, Salvatore Marullo, Floriana Billeci, and Francesca D’Anna. Eur. J. Org. Chem. 2021 , 3148–3169. doi.org/10.1002/ejoc.202100372. DÍA, HORA y LUGAR : Lunes 30 de agosto de 2021, 18:00 h, Plataforma MEET GOOGLE. Link :  meet.google.com/bfh-poxv-bso RESUMEN :   Supramolecular gels are a fascinating class of materials, originated by the self-assembly of low molecular weight molecules. Underpinned by non-covalent interactions, they find application in a diverse range of fields. Among these, supramolecular gels can be considered as organized, nonconventional reaction media, able to influence reactivity in a radically different way, compared with what happens in solution. This short review will focus on this aspect, covering literature from 2010 onwards, addressing the application of supramolecu...

SEMINARIO QUÍMICA ORGÁNICA 23-08-21 EXPOSITOR :  Farm. Marianela Pizzio TÍTULO :  " Boronic Acids and Their Derivatives in Medicinal Chemistry: Synthesis and Biological Applications " . FUENTE :   Mariana Pereira Silva, Lucília Saraiva, Madalena Pinto and Maria Emília Sousa, Molecules 2020 , 25 , 4323; doi:10.3390/molecules25184323. DÍA, HORA y LUGAR : Lunes 23 de agosto de 2021, 18:00 h, Plataforma MEET GOOGLE. Link :  meet.google.com/bfh-poxv-bso RESUMEN : Boron containing compounds have not been widely studied in Medicinal Chemistry, mainly due to the idea that this group could confer some toxicity. Nowadays, this concept has been demystified and, especially after the discovery of the drug bortezomib, the interest for these compounds, mainly boronic acids, has been growing. In this review, several activities of boronic acids, such as anticancer, antibacterial, antiviral activity, and even their application as sensors and delivery systems are addressed. The synthe...

SEMINARIO QUÍMICA ORGÁNICA 09-08-21 EXPOSITOR :   Dr.  Ariel M. Sarotti TÍTULO :   "Lessons in Strain and Stability: Enantioselective Synthesis of (+)-[5]-Ladderanoic Acid" . FUENTE :   Erin N. Hancock, Erin L. Kuker, Prof. Dean J. Tantillo, Prof. M. Kevin Brown. Angew. Chem. Int. Ed.,  2020 ,  59 , 436-441. DÍA, HORA y LUGAR : Lunes 9 de agosto de 2021, 18:00 h, Plataforma MEET GOOGLE. Link :  meet.google.com/bfh-poxv-bso RESUMEN :   The synthesis of structurally complex and highly strained natural products provides unique challenges and unexpected opportunities for the development of new reactions and strategies. Herein, the synthesis of (+)-[5]-ladderanoic acid is reported. En route to the target, unusual and unexpected strain release driven transformations were uncovered. This occurrence required a drastic revision of the synthetic design that ultimately led to the development of a novel stepwise cyclobutane assembly by an allylboration/Zweife...