13° SEMINARIO QUÍMICA ORGÁNICA IQUIR 2021

SEMINARIO QUÍMICA ORGÁNICA 09-08-21

EXPOSITOR: Dr. Ariel M. Sarotti

TÍTULO: "Lessons in Strain and Stability: Enantioselective Synthesis of (+)-[5]-Ladderanoic Acid".

FUENTE: Erin N. Hancock, Erin L. Kuker, Prof. Dean J. Tantillo, Prof. M. Kevin Brown. Angew. Chem. Int. Ed., 2020, 59, 436-441.

DÍA, HORA y LUGAR: Lunes 9 de agosto de 2021, 18:00 h, Plataforma MEET GOOGLE.

Link: meet.google.com/bfh-poxv-bso

RESUMEN: The synthesis of structurally complex and highly strained natural products provides unique challenges and unexpected opportunities for the development of new reactions and strategies. Herein, the synthesis of (+)-[5]-ladderanoic acid is reported. En route to the target, unusual and unexpected strain release driven transformations were uncovered. This occurrence required a drastic revision of the synthetic design that ultimately led to the development of a novel stepwise cyclobutane assembly by an allylboration/Zweifel olefination sequence.

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