SEMINARIOS AREA QUÍMICA ORGÁNICA FBIOYF/IQUIR

  SEMINARIO QUÍMICA ORGÁNICA 6-12-21 EXPOSITOR : Qco. Juan M. Ramos M. TÍTULO :  " Unified Synthesis of Polycyclic Alkaloids by Complementary Carbonyl Activation " . FUENTE : Guoli He, Benjamin List,* and Mathias Christmann*, Angew. Chem. Int. Ed. 2021 , 60 , 13591–13596. DÍA, HORA y LUGAR : Lunes 6 de diciembre de 2021, 18:00 h, Plataforma MEET GOOGLE. Link :  meet.google.com/bfh-poxv-bso RESUMEN :  A complementary dual carbonyl activation strategy for the synthesis of polycyclic alkaloids has been developed. Successful applications include the synthesis of tetracyclic alkaloids harmalanine and harmalacinine, pentacyclic indoloquinolizidine alkaloid nortetoyobyrine, and octacyclic bcarboline alkaloid peganumine A. The latter synthesis features a protecting-group-free assembly and an asymmetric disulfonimide-catalyzed cyclization. Furthermore, formal syntheses of hirsutine, deplancheine, 10-desbromoarborescidine A, and oxindole alkaloids rhynchophylline and isorhy...

SEMINARIO QUÍMICA ORGÁNICA 29-11-21 EXPOSITOR :   Lic. Nadia L. Martiren TÍTULO :  " Enantioselective Total Synthesis of (+)-Heilonine " . FUENTE :   Kyle J. Cassaidy and Viresh H. Rawal,   J. Am. Chem. Soc. 2021 , 143 , 16394-16400. DÍA, HORA y LUGAR : Lunes 29 de noviembre de 2021, 18:00 h, Plataforma MEET GOOGLE. Link :  meet.google.com/bfh-poxv-bso RESUMEN : Chemical transformations that rapidly and efficiently construct a high level of molecular complexity in a single step are perhaps the most valuable in total synthesis. Among such transformations is the transition metal catalyzed [2 + 2 + 2] cycloisomerization reaction, which forges three new C–C bonds and one or more rings in a single synthetic operation. We report here a strategy that leverages this transformation to open de novo access to the Veratrum family of alkaloids. The highly convergent approach described herein includes (i) the enantioselective synthesis of a diyne fragment containing the ster...

SEMINARIO QUÍMICA ORGÁNICA 08-11-21 EXPOSITOR :   Lic. Alejandro Recio Balsells TÍTULO :  " Fexinidazol el primer tratamiento completamente oral para la enfermedad del sueño " . FUENTE :   1-https://dndi.org/press-releases/2021/us-fda-approves-fexinidazole-as-first-all-oral-treatment-sleeping-sickness/  2- Trop. Med. Infect. Dis. 2020 , 5(1), 17; doi: 10.3390/tropicalmed5010017 )  3- Bioorg Med Chem Lett. 2011 ; 21(3):1015-8. doi: 10.1016/j.bmcl.2010.12.040.  4- J. Org. Chem. 2015 , 80, 21, 10498–10504; doi: 10.1021/acs.joc.5b02133. DÍA, HORA y LUGAR : Lunes 8 de noviembre de 2021, 17:00 h, Plataforma MEET GOOGLE. Link :  meet.google.com/bfh-poxv-bso RESUMEN :   Recientemente la FDA ha aprobado el uso de Fexinidazol para el tratamiento de la Tripanosomiasis Humana Africana en sus dos estadios. Este desarrollo es de suma importancia debido a que el tratamiento es completamente oral, reemplazando tratamientos previos en los cuales era necesario ...