SEMINARIOS AREA QUÍMICA ORGÁNICA FBIOYF/IQUIR

SEMINARIO QUÍMICA ORGÁNICA 06-06-22 EXPOSITOR :  Lic. Soledad Cicetti TÍTULO :  " Audible sound-controlled spatiotemporal patterns in out-of-equilibrium systems " . FUENTE :  Ilha Hwang, Rahul Dev Mukhopadhyay, Prabhu Dhasaiyan, Seoyeon Choi, Soo-Young Kim, Young Ho Ko, Kangkyun Baek and Kimoon Kim Nature Chemistry volume 12, pages 808–813 ( 2020 ). DÍA, HORA y LUGAR : Lunes 6 de junio de 2022, 18:00 h.  Plataforma MEET GOOGLE. Link :  meet.google.com/bfh-poxv-bso RESUMEN :   Naturally occurring spatiotemporal patterns typically have a predictable pattern design and are reproducible over several cycles. However, the patterns obtained from artificially designed out-of-equilibrium chemical oscillating networks (such as the Belousov–Zhabotinsky reaction for example) are unpredictable and difficult to control spatiotemporally, albeit reproducible over subsequent cycles. Here, we show that it is possible to generate reproducible spatiotemporal patterns in out-...

  SEMINARIO QUÍMICA ORGÁNICA 30-05-22 EXPOSITOR :  Dra. Carina M. L. Delpiccolo TÍTULO :  " Biotransformation: Impact and Application of Metabolism in Drug Discovery " . FUENTE : Julia Shanu-Wilson, Liam Evans, Stephen Wrigley, Jonathan Steele, James Atherton, and Jason Boer ACS Med. Chem. Lett. 2020 , 11 , 2087−2107 . DÍA, HORA y LUGAR : Lunes 30 de mayo de 2022, 12:30 h, Aula 18 (graduados), Fac. Cs. Bioq. y Farmac. RESUMEN : Biotransformation has a huge impact on the efficacy and safety of drugs. Ultimately the effects of metabolism can be the lynchpin in the discovery and development cycle of a new drug. This article discusses the impact and application of biotransformation of drugs by mammalian systems, microorganisms, and recombinant enzymes, covering active and reactive metabolites, the impact of the gut microbiome on metabolism, and how insights gained from biotransformation studies can influence drug design.

SEMINARIO QUÍMICA ORGÁNICA 23-05-22 EXPOSITOR :  Lic. Federico Dezotti TÍTULO :  " Catalysis with Diboron(4)/Pyridine: Application to the Broad-Scope [3 + 2] Cycloaddition of Cyclopropanes and Alkenes " . FUENTE :  Zhengwei Ding, Zhi Liu, Zhijun Wang, Tao Yu, Ming Xu, Jingru Wen, Kaiyan Yang, Hailong Zhang, Liang Xu, and Pengfei Li, J. Am. Chem. Soc., 2022, 144, 19, 8870–8882. DÍA, HORA y LUGAR : Lunes 23 de mayo de 2022, 18:00 h, Plataforma MEET GOOGLE. Link :  meet.google.com/bfh-poxv-bso RESUMEN : In contrast to the extensive but non-recyclable use of tetraalkoxydiboron(4) compounds as stoichiometric reagents in diverse reactions, this article reports an atom-economical reaction using a commercial diboron(4) as the catalyst. The key to success was designing a catalytic cycle for radical [3 + 2] cycloaddition involving a pyridine cocatalyst to generate from the diboron(4) catalyst and reversibly mediate the transfer of boronyl radicals. In comparison with known [3...

SEMINARIO QUÍMICA ORGÁNICA 16-05-22 EXPOSITOR : Lic. Darián Vazquez TÍTULO :  " Asymmetric total synthesis of (1S,2S,4S)-β-elemene " . FUENTE :  Wei Chen, Zhun Feng and Qiang Liu ,  RSC Adv. , 2022 , 12 , 8249. DÍA, HORA y LUGAR : Lunes 16 de mayo de 2022, 18:00 h, Plataforma MEET GOOGLE. Link :  meet.google.com/bfh-poxv-bso RESUMEN : Elemenes are sesquiterpene natural products extracted from Chinese medicinal herbs and have been used as an important antitumor drug in China. Here, we report the first stereoselective total synthesis of (1S,2S,4S)-b-elemene using (R)-carvone as a chiral pool starting material. The isopropenyl moiety was achieved in a highly stereoselective manner through 1,4-Michael conjugate addition. The following transformations like regio- and stereoselective aldol condensation, Wittig olefination have been employed as the key steps, resulting in a concise total synthesis of (1S,2S,4S)-b-elemene. Our accomplishment will allow further biological in...

SEMINARIO QUÍMICA ORGÁNICA 09-05-22 EXPOSITOR : Dr. Martín J. Riveira TÍTULO :  " cis -THC " . FUENTE : M. A. Schafroth, G. Mazzoccanti, I. Reynoso-Moreno, R. Erni, F. Pollastro, D. Caprioglio, B. Botta, G. Allegrone, G. Grassi, A. Chicca, F. Gasparrini, J. Gertsch, E. M. Carreira, and G. Appendino, J. Nat. Prod. 2021 , 84 , 2502-2510. DÍA, HORA y LUGAR : Lunes 9 de mayo de 2022, 18:00 h, Plataforma MEET GOOGLE. Link :  meet.google.com/bfh-poxv-bso RESUMEN :  La química de fitocannabinoides ha sido testigo de un renovado interés estas últimas décadas como consecuencia de reducciones en las restricciones para investigar estas sustancias, el conocimiento científico creciente sobre el sistema endocannabinoide y el desarrollo de tratamientos aprobados. A pesar de los grandes avances y la larga historia de la química de los componentes del cannabis medicinal, la mayoría de los estudios han estado centrados en dos de los principales componentes: cannabidiol (CBD) and (-)- tran...