9° SEMINARIO QUÍMICA ORGÁNICA IQUIR 2022

SEMINARIO QUÍMICA ORGÁNICA 30-05-22

EXPOSITOR: Dra. Carina M. L. Delpiccolo

TÍTULO: "Biotransformation: Impact and Application of Metabolism in Drug Discovery".

FUENTE: Julia Shanu-Wilson, Liam Evans, Stephen Wrigley, Jonathan Steele, James Atherton, and Jason Boer ACS Med. Chem. Lett. 2020, 11, 2087−2107.

DÍA, HORA y LUGAR: Lunes 30 de mayo de 2022, 12:30 h, Aula 18 (graduados), Fac. Cs. Bioq. y Farmac.

RESUMEN: Biotransformation has a huge impact on the efficacy and safety of drugs. Ultimately the effects of metabolism can be the lynchpin in the discovery and development cycle of a new drug. This article discusses the impact and application of biotransformation of drugs by mammalian systems, microorganisms, and recombinant enzymes, covering active and reactive metabolites, the impact of the gut microbiome on metabolism, and how insights gained from biotransformation studies can influence drug design.

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