18º SEMINARIO QUÍMICA ORGÁNICA IQUIR 2025

SEMINARIO QUÍMICA ORGÁNICA 8-9-25

EXPOSITOR: Lic. Tomás A. Dómina

TÍTULO: "Bidentate N-ligand-assisted gold redox catalysis with hydrogen peroxide".

FUENTE: Hongwei Shi, Matthias Rudolph, Jun Li, Yu Tian, Martin C. Dietl, Hadil Alshurafa, Yaowen Liu, Tao Wang, Henrik Habeck, Philipp M. Stein, Petra Krämer, Frank Rominger, Thomas Oeser, Ning Jiao & A. Stephen K. Hashmi. Nat. Chem. 2025, 17, 822–834. https://doi.org/10.1038/s41557-025-01835-7

DÍA, HORA y LUGAR: Lunes 8 de septiembre de 2025, 14:00 h, Aula 18 y virtual.

Modalidad virtual, Link: meet.google.com/hjn-ygro-twf (Plataforma MEET GOOGLE)

Resumen: Gold redox catalysis, which exploits the ability of strong π-acid activation in combination with redox reactions, has emerged as an attractive synthetic method with unique reactivities compared to other transition metals. However, gold redox chemistry bears the challenge to overcome the high redox potential of Au(I)/Au(III) (1.41 V). The classical strategy of gold redox catalysis applies strong external chemical oxidants which inevitably results in low atom economy and substrate limitations due to incompatibility with functional groups. Here we report a bidentate N-ligand (for example, Phen, Bpy) assisted gold redox catalysis using H2O2 as oxidant, which proved to be generally applicable for many forms of coupling reactions. In addition, C(sp2)–C(sp2) bicyclization coupling (cross-coupling of two cyclized substrates) is accessible under our conditions. Mechanistic studies reveal a redox elimination process in which a bidentate N-ligand is crucial for the catalytic cycle. The formation of alkynyl-Au(III)–OH and vinyl-Au(III)–OH species is the key process for the synergistic π-bond activation and Au(I) oxidation.