SEMINARIOS AREA QUÍMICA ORGÁNICA FBIOYF/IQUIR

SEMINARIO QUÍMICA ORGÁNICA 2-6-25 EXPOSITOR :  Dr. Ariel M. Sarotti TÍTULO :   " Toward Chiral Recognition by Design: Uncovering the Self-Enantioresolving Properties of Chiral Amine Derivatives " FUENTE : Anka Hagelschuer, Damián Padín, Vanda Dašková, Ben L. Feringa. J. Am. Chem. Soc. 2025, ASAP. https://doi.org/10.1021/jacs.5c01251 DÍA, HORA y LUGAR : Lunes 2 de junio de 2025, 14:00 h, Aula 18 y virtual. Modalidad virtual, Link :  meet.google.com/hjn-ygro-twf  ( Plataforma MEET GOOGLE) Resumen :  The study of chiral recognition phenomena is key for understanding biological processes, designing bioactive compounds, and for asymmetric catalysis and chiral analysis. In addition, phenomena related to the self-recognition of enantiomers are highly relevant in emergence-of-homochirality research and supramolecular chemistry. However, the design of molecules exhibiting chiral self-recognition remains challenging, and its observation is mainly based on serendipity. He...

SEMINARIO QUÍMICA ORGÁNICA 26-5-25 EXPOSITOR :  Lic. Enzo F. G. Centurión TÍTULO :   " De Novo Synthesis of Dihydrobenzofurans and Indolines and Its Application to a Modular, Asymmetric Synthesis of Beraprost " FUENTE :   Ze-Shu Wang et al .  J. Am. Chem. Soc. 2023 , 145 , 14124–14132.  https://doi.org/10.1021/jacs.3c04582 DÍA, HORA y LUGAR : Lunes 26 de mayo de 2025, 14:00 h, Aula 18 y virtual. Modalidad virtual, Link :  meet.google.com/hjn-ygro-twf  ( Plataforma MEET GOOGLE) Resumen : Dihydrobenzofurans and indolines are important constituents of pharmaceuticals. Herein, we describe a novel strategy for their construction in which the aromatic ring is created de novo through an inverse-electron demand Diels–Alder reaction and cheletropic extrusion sequence of a 2-halothiophene-1,1-dioxide with an enol ether/enamide, followed by aromatization. Unusually, the aromatization process proved to be highly challenging, but it was discovered that treatment o...

SEMINARIO QUÍMICA ORGÁNICA 19-5-25 EXPOSITOR :  Lic. Matías Krivoy TÍTULO :   " Synthesis and in vitro and in silico studies of 1H- and 2H-1,2,3-triazoles as antichagasic agents " FUENTE :   Thais B. Silva et al. Bioorganic Chemistry , 2021 , 116 , 105250. https://www.sciencedirect.com/science/article/pii/S0045206821006271 DÍA, HORA y LUGAR : Lunes 19 de mayo de 2025, 14:00 h, Aula 18 y virtual. Modalidad virtual, Link :  meet.google.com/hjn-ygro-twf  ( Plataforma MEET GOOGLE) Resumen :  1,2,3-triazole heterocycles stand out in medicinal chemistry for having great structural diversity and bioactivities. In this study, two series of triazoles were synthesized. One was obtained by the 1,3-dipolar cycloaddition reaction between ethyl cyanoacetate and several phenyl azides forming 1H-1,2,3-triazoles and the other by rearrangement of Dimroth forming and 2H-1,2,3-triazoles. Both series were shown to be active against the epimastigote form of Trypanosoma cruzi. Th...

SEMINARIO QUÍMICA ORGÁNICA 12-5-25 EXPOSITOR :  Dra. Agustina La Venia TÍTULO :   " Recent Progress and Prospects of Small Molecules for NLRP3 Inflammasome Inhibition " FUENTE :  Ying Chen, et al. Cell. Mol. Biol. Lett.  2023 ,  28 , 51 . Na Li, et al.  J. Med. Chem. 2023 , 66 ,   14447-14473. DÍA, HORA y LUGAR : Lunes 12 de mayo de 2025, 14:00 h, Aula 18 y virtual. Modalidad virtual, Link :  meet.google.com/hjn-ygro-twf  ( Plataforma MEET GOOGLE) Resumen : NLRP3 inflammasome is a multiprotein complex involved in host immune response which exerts various biological effects by mediating the maturation and secretion of IL-1β and IL-18and pyroptosis. However, its aberrant activation could cause amplification of inflammatory effects, thereby triggering a range of ailments, including Alzheimer’s disease, Parkinson’s disease, rheumatoid arthritis, gout, type 2 diabetes mellitus, and cancer. For the past few years, as an attractive anti-inflammato...

SEMINARIO QUÍMICA ORGÁNICA 5-5-25 EXPOSITOR :  Qco. Arturo Mendoza Salgado TÍTULO :   " Total Syntheses of Uvarindoles A and B, (±)-Pseudophrynaminol, and (±)-Pseudophrynamines 272A and 270 via Dearomative Indole Alkylation " FUENTE : Raju Chouhan and Sajal Kumar Das,  J. Org. Chem. 2025 , 90 , 5062–5065. DÍA, HORA y LUGAR : Lunes 5 de mayo de 2025, 14:00 h, Aula 18 y virtual. Modalidad virtual, Link :  meet.google.com/hjn-ygro-twf  ( Plataforma MEET GOOGLE) Resumen :   Herein, we report the first total synthesis of alkaloid uvarindole B with an overall yield of 49% over five steps via double C3-alkylation of 5-bromoindole, Plancher rearrangement, and Negishi coupling as the key steps. We also disclose short total syntheses of uvarindole A, pseudophrynaminol, and pseudophrynamines 272A and 270 via dearomative indole alkylation.

SEMINARIO QUÍMICA ORGÁNICA 28-4-25 EXPOSITOR :  Qco. Liddier Pérez Hincapié TÍTULO :   " Chiral N-Alkylfluorenyl-Substituted N-Heterocyclic Carbenes In The Gold(I)-Catalyzed Enantioselective Cycloisomerization Of 1,6-Enynes " FUENTE :   Robin Heinrich, Giovany Marie-Rose, Christophe Gourlaouen, Patrick Pale,Eric Brenner, and Aurélien Blanc, Chem. Eur. J. 2025,  31, e202404446 DÍA, HORA y LUGAR : Lunes 28 de abril de 2025, 14:00 h, Aula 18 y virtual. Modalidad virtual, Link :  meet.google.com/hjn-ygro-twf  ( Plataforma MEET GOOGLE) Resumen :        A series of chiral A*Flu-NHC-gold(I) complexes, where A*Flu-NHC is an N-heterocyclic carbene (imidazolin-2-ylidene or benzimidazolin-2-ylidene) bearing a chiral 9-alkyl-9-fluorenyl N-substituent and a 2,6-diisopropylphenyl or benzyl N’-substituent, were straightforwardly prepared in few steps from readily available 2,6-diisopropylamine, imidazole or benzimidazole. The chirality of the N-su...

SEMINARIO QUÍMICA ORGÁNICA 21-4-25 EXPOSITOR :  Dra. Noelia S. Medrán TÍTULO :   " Péptidos como sustitutos de Agroquímicos " FUENTE :   1- Leandro Pereira-Dias, Paulo R. Oliveira-Pinto, Juliana O. Fernandes, Laura Regalado, Rafael Mendes, Cátia Teixeira, Nuno Mariz-Ponte, Paula Gomes, Conceição Santos, "Peptaibiotics: Harnessing the potential of microbial secondary metabolites for mitigation of plant pathogens", Biotechnology Advances , 2023 , 68 , 108223.  2- Yimeng Zhang, Yan Liu, Xiaoqing Wu, Xingxing Lu, Meizi Wang, Dexing Ye, Chandni Iqbal, Wenyu Sun, Xinyuan Zhang, Li Zhang, and Xinling Yang, "A Novel Peptidomimetic Insecticide: Dippu -AstR-Based Rational Design and Biological Activity of Allatostatin Analogs", Journal of Agricultural and Food Chemistry , 2024 , 72 , 11341-11350.  3- De Zotti, M.; Sella, L.; Bolzonello, A.; Gabbatore, L.; Peggion, C.; Bortolotto, A.; Elmaghraby, I.; Tundo, S.; Favaron, F. "Targeted Amino Acid Substitution...