SEMINARIOS AREA QUÍMICA ORGÁNICA FBIOYF/IQUIR

SEMINARIO QUÍMICA ORGÁNICA 4-8-25 EXPOSITOR :   Ing. Natalia Lenarduzzi TÍTULO :   " Asymmetric Total Synthesis of 4,9,10-Trihydroxyguaia-11(13)en-12,6-olide and Discovery of Its Anticancer Activity against Atypical Teratoid Rhabdoid Tumor ". FUENTE :   Hyejin Lee, et al. ACS Cent. Sci. 2025 , 11 , 7, 1103–1110. https://doi.org/10.1021/acscentsci.5c00332 . DÍA, HORA y LUGAR : Lunes 4 de agosto de 2025, 14:00 h, Aula 18 y virtual. Modalidad virtual, Link :  meet.google.com/hjn-ygro-twf  ( Plataforma MEET GOOGLE) Resumen : The guaianolide family of sesquiterpene lactones is known for its distinctive structural features and diverse biological activities. 4,9,10-Trihydroxyguaia-11(13)en-12,6-olide, with an underdetermined absolute stereochemistry (1 or ent-1), is a newly identified 6,12-guaianolide isolated from the genus Anvillea garcinii. Motivated by the potential biological activity of the natural product, we pursue its stereoselective synthesis. Starting from...

  SEMINARIO QUÍMICA ORGÁNICA 30-6-25 EXPOSITOR :  Lic. Josefina Huck TÍTULO :   " Iron-Catalyzed Enantioselective Multicomponent Cross-Couplings of α -Boryl Radicals ". FUENTE :   Cassandra R. Youshaw, et al. Org. Lett. 2023 , 25, 46, 8320–8325. https://doi.org/10.1021/acs.orglett.3c03387 . DÍA, HORA y LUGAR : Lunes 30 de junio de 2025, 14:00 h, Aula 18 y virtual. Modalidad virtual, Link :  meet.google.com/hjn-ygro-twf  ( Plataforma MEET GOOGLE) Resumen : Despite recent interest in the development of iron-catalyzed transformations, methods that use iron-based catalysts capable of controlling the enantioselectivity in carbon–carbon cross-couplings are underdeveloped. Herein, we report a practical and simple protocol that uses commercially available and expensive iron salts in combination with chiral bisphosphine ligands to enable the regio- and enantioselective (up to 91:9) multicomponent cross-coupling of vinyl boronates, (fluoro)alkyl halides, and Grigna...

SEMINARIO QUÍMICA ORGÁNICA 23-6-25 EXPOSITOR :  Dr. Teodoro S. Kaufman TÍTULO :   " Síntesis total de isodaflongamina H mediante la cicloadición reductiva [3 + 2] de una N-hidroxilactama catalizada por iridio ". FUENTE : Sora Iwamoto et al , Angew. Chem. Int. Ed. ,  2025 ,   https://doi.org/10.1002/anie.202508062. DÍA, HORA y LUGAR : Lunes 23 de junio de 2025, 14:00 h, Aula 18 y virtual. Modalidad virtual, Link :  meet.google.com/hjn-ygro-twf  ( Plataforma MEET GOOGLE) Resumen : Se describe la síntesis de isodaflongamina H sobre la base de una “estrategia de lactamas”, que permite un acceso rápido a aminas cíclicas complejas desde lactamas fácilmente accesibles. Varios de los intermediarios y el producto final mostraron citotoxicidad frente a las líneas celulares HeLa y U937, sugiriendo que éstos podrían convertirse en un compuesto clave para futuros estudios biológicos.

SEMINARIO QUÍMICA ORGÁNICA 9-6-25 EXPOSITOR :  Lic. Benjamín A. Pisaroni TÍTULO :   " Thioxanthone Synthesis from Thioureas through Double Aryne Insertion into a Carbon-Sulfur Double Bond ". FUENTE : Mayu Kawada, Shinya Tabata, Yukitaka Hoshi, and Suguru Yoshida https://doi.org/10.1021/acs.orglett.4c04490 Org. Lett. 2025 , 27 , 827−832. DÍA, HORA y LUGAR : Lunes 9 de junio de 2025, 14:00 h, Aula 18 y virtual. Modalidad virtual, Link :  meet.google.com/hjn-ygro-twf  ( Plataforma MEET GOOGLE) Resumen :  Thioxanthone synthesis from o-silylaryl triflates and thioureas is disclosed. Double aryne insertion into the C=S double bond of thioureas and subsequent hydrolysis realized the facile preparation of thioxanthones. A simple reaction procedure and good accessibility of o-silylaryl triflates allowed us to synthesize a wide range of highly functionalized thioxanthones.

SEMINARIO QUÍMICA ORGÁNICA 2-6-25 EXPOSITOR :  Dr. Ariel M. Sarotti TÍTULO :   " Toward Chiral Recognition by Design: Uncovering the Self-Enantioresolving Properties of Chiral Amine Derivatives " FUENTE : Anka Hagelschuer, Damián Padín, Vanda Dašková, Ben L. Feringa. J. Am. Chem. Soc. 2025, ASAP. https://doi.org/10.1021/jacs.5c01251 DÍA, HORA y LUGAR : Lunes 2 de junio de 2025, 14:00 h, Aula 18 y virtual. Modalidad virtual, Link :  meet.google.com/hjn-ygro-twf  ( Plataforma MEET GOOGLE) Resumen :  The study of chiral recognition phenomena is key for understanding biological processes, designing bioactive compounds, and for asymmetric catalysis and chiral analysis. In addition, phenomena related to the self-recognition of enantiomers are highly relevant in emergence-of-homochirality research and supramolecular chemistry. However, the design of molecules exhibiting chiral self-recognition remains challenging, and its observation is mainly based on serendipity. He...

SEMINARIO QUÍMICA ORGÁNICA 26-5-25 EXPOSITOR :  Lic. Enzo F. G. Centurión TÍTULO :   " De Novo Synthesis of Dihydrobenzofurans and Indolines and Its Application to a Modular, Asymmetric Synthesis of Beraprost " FUENTE :   Ze-Shu Wang et al .  J. Am. Chem. Soc. 2023 , 145 , 14124–14132.  https://doi.org/10.1021/jacs.3c04582 DÍA, HORA y LUGAR : Lunes 26 de mayo de 2025, 14:00 h, Aula 18 y virtual. Modalidad virtual, Link :  meet.google.com/hjn-ygro-twf  ( Plataforma MEET GOOGLE) Resumen : Dihydrobenzofurans and indolines are important constituents of pharmaceuticals. Herein, we describe a novel strategy for their construction in which the aromatic ring is created de novo through an inverse-electron demand Diels–Alder reaction and cheletropic extrusion sequence of a 2-halothiophene-1,1-dioxide with an enol ether/enamide, followed by aromatization. Unusually, the aromatization process proved to be highly challenging, but it was discovered that treatment o...

SEMINARIO QUÍMICA ORGÁNICA 19-5-25 EXPOSITOR :  Lic. Matías Krivoy TÍTULO :   " Synthesis and in vitro and in silico studies of 1H- and 2H-1,2,3-triazoles as antichagasic agents " FUENTE :   Thais B. Silva et al. Bioorganic Chemistry , 2021 , 116 , 105250. https://www.sciencedirect.com/science/article/pii/S0045206821006271 DÍA, HORA y LUGAR : Lunes 19 de mayo de 2025, 14:00 h, Aula 18 y virtual. Modalidad virtual, Link :  meet.google.com/hjn-ygro-twf  ( Plataforma MEET GOOGLE) Resumen :  1,2,3-triazole heterocycles stand out in medicinal chemistry for having great structural diversity and bioactivities. In this study, two series of triazoles were synthesized. One was obtained by the 1,3-dipolar cycloaddition reaction between ethyl cyanoacetate and several phenyl azides forming 1H-1,2,3-triazoles and the other by rearrangement of Dimroth forming and 2H-1,2,3-triazoles. Both series were shown to be active against the epimastigote form of Trypanosoma cruzi. Th...