16° SEMINARIO QUÍMICA ORGÁNICA IQUIR 2022

SEMINARIO QUÍMICA ORGÁNICA 22-08-22

EXPOSITOR: Qco. Msc. Javier Cala

TÍTULO: "Lactamización descostructiva selectiva del esqueleto de indolo[2,3-a]quinolizina para la sintesis total de (+) y (-) - custamina".

FUENTE: A. Recoba-Torres, S. Cruz-Gregorio, L. Quintero, J. Sandoval-Lira, J. Romero-Ibañez, F. Sartillo-Piscil, Eur. J. Org. Chem., 2022, e202200292. DOI: doi.org/10.1002/ejoc.202200292.

DÍA, HORA y LUGAR: Lunes 22 de agosto de 2022, 14:00 h, Aula 18 FBIOYF.

Modalidad virtual, Link: meet.google.com/hjn-ygro-twf (Plataforma MEET GOOGLE)

RESUMEN: The general approach for accessing to a tetracyclic hexahydro-3H-indolizino[8,7-b]indol-3-one alkaloids is that what involves the construction of the γ-lactam ring from a tricyclic precursor. Here in this report, we disclose a new synthetic strategy that permits the direct deconstruction of the tetracyclic indolo[2,3-a]quinolizine motif into the tetracyclic hexahydroindolizin-3-one scaffold of the naturally occurring (+)-cuscutamine without the use of either transition or precious metals. Additionally, the current total synthesis of both enantiomers provides structural clarification of the natural occurring alkaloid.

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