14° SEMINARIO QUÍMICA ORGÁNICA IQUIR 2024

SEMINARIO QUÍMICA ORGÁNICA 19-8-24

EXPOSITOR: Lic. Tomás A. Dómina

TÍTULO: "Diastereo- and Enantioselective Chemodivergent Three-Component Cascade Reactions via Gold and Carbene Sequential Catalysis"

FUENTE: Shulei Zhang, Shao-Jie Wang, Xiaolan Xin, Xia Wang, Zhifeng Tu y Shenci Lu, ACS Catal. 2024, 14, 12, 9275-9282 https://doi.org/10.1021/acscatal.4c02157

DÍA, HORA y LUGAR: Lunes 19 de agosto de 2024, 14:00 h, virtual.

Modalidad virtual, Link: meet.google.com/hjn-ygro-twf (Plataforma MEET GOOGLE)

Resumen: This study investigates the feasibility and inherent benefits of combining transition-metal- and organoasymmetric-catalyzed reactions in one pot. The reported transformation features Au-catalyzed tandem hydration–oxacyclization and NHC-catalyzed enantioselective annulation, effectively converting simple skipped diynones, water, and enals into highly diastereo- and enantioenriched fused heterocycles. Furthermore, the chemoselectivity controlled by the base is particularly noteworthy, enabling facile access to ε-lactones or spiro heterocycles from the same set of starting materials.

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