20º SEMINARIO QUÍMICA ORGÁNICA IQUIR 2025

SEMINARIO QUÍMICA ORGÁNICA 22-9-25

EXPOSITOR: Lic. Lucía Gurgone

TÍTULO: "Synthesis of the Cannabimovone and Cannabifuran Class of Minor Phytocannabinoids and Their Anti-inflammatory Activity".

FUENTE: David G. Dennis, Shravanthi D. Anand, Angel J. Lopez, Jan Petrovčič, Aditi Das, and David Sarlah.The Journal of Organic Chemistry 2022 87 (9), 6075-6086.

DÍA, HORA y LUGAR: Lunes 22 de septiembre de 2025, 14:00 h, Aula 18 y virtual.

Modalidad virtual, Link: meet.google.com/hjn-ygro-twf (Plataforma MEET GOOGLE)

Resumen: Despite centuries-long use of Cannabis in human culture and the now ubiquitous claims of its medicinal value, only a small handful of phytocannabinoids have been rigorously evaluated for pharmacological properties. While more than 100 distinct minor cannabinoids have been documented to date, a paucity of studies on their biological activities have been conducted due to a lack of routine access to sufficient quantities for testing. Herein, we report a strategy to prepare several structurally diverse minor cannabinoids deriving synthetically from readily available cannabidiol. Furthermore, we examined their ability to polarize activated microglia toward an anti-inflammatory phenotype using LPS-stimulated BV2 microglial cells. The minor cannabinoids studied, especially cannabielsoin, dehydrocannabielsoin, cannabimovone, and 3′-epicannabimovone, inhibited the production of prototypical pro-inflammatory biomarkers. This study represents the beginning of a systematic mapping of the roles minor cannabinoids may play in the medicinal properties of cannabis used for the treatment of pain and inflammation.