SEMINARIOS AREA QUÍMICA ORGÁNICA FBIOYF/IQUIR

SEMINARIO QUÍMICA ORGÁNICA 03-05-21 EXPOSITOR : Lic. Soledad Cicetti TÍTULO :   "Determinación de la configuración absoluta de compuestos con una super-cadena-carbonada mediante un enfoque químico, espectroscópico y computacional combinado: Gibbosoles A y B" FUENTE :   Li, W.; Yan, R.; Yu, Y.; Shi, Z.; Mándi, A.; Shen, L.; Kurtán, T.; Wu, J. Angew. Chem. 2020 , 132 (31), 13128−13136. DÍA, HORA y LUGAR : Lunes 10 de mayo de 2021, 18:00 h, Plataforma MEET GOOGLE. Link :  meet.google.com/bfh-poxv-bso RESUMEN :   Los dinoflagelados marinos producen notables compuestos orgánicos, en particular aquellos cuyas estructuras presentan largas cadenas carbonadas polioxigenadas, denominados compuestos de súper cadenas carbonadas (SCCCs por sus siglas en inglés, caracterizados por la presencia de un gran número de centros estereogénicos en cadenas carbonadas acíclicas. Aun hoy en día, representa un gran desafío la determinación de la configuración absoluta de estas moléculas. E...

SEMINARIO QUÍMICA ORGÁNICA 19-04-21 EXPOSITOR : Dra. Agustina La Venia TÍTULO :  " REACCIONES BIOORTOGONALES. EJEMPLO DE UNA PROPUESTA DE UNA NUEVA ALTERNATIVA REACCIÓN: “The Bioorthogonal Isonitrile−Chlorooxime Ligation” " FUENTE :   1) Rebecca J. B. Schäfer, Mattia R. Monaco, Mao Li, Alina Tirla, Pablo Rivera-Fuentes, Helma Wennemers J. Am. Chem. Soc. 2019 , 141 , 18644; Selected reviews: 2) Milán Vrabel et al, Top Curr Chem (Z) 2016 , 374:9; 3) N K Devaraj ACS Cent. Sci. 2018 , 4, 952; 4) Bonger et al Current Opinion in Chemical Biology 2021 , 60:79; 5) R M Franzini Chem Rev 2021 in press. DÍA, HORA y LUGAR : Lunes 19 de abril de 2021, 18:00 h, Plataforma MEET GOOGLE. Link :  meet.google.com/bfh-poxv-bso RESUMEN :   The emergence of bioorthogonal reactions has greatly advanced research in the fields of biology and medicine. They are not only valuable for labeling, tracking, and understanding biomolecules within living organisms, but also important for construct...

SEMINARIO QUÍMICA ORGÁNICA 12-04-21 EXPOSITOR : Dra. Noelia Medrán TÍTULO :  " Peptidomimetic toolbox for drug discovery. Local modifications, global restrictions " FUENTE :  (a) Elena Lenci and Andrea Trabocchi, " Peptidomimetic toolbox for drug discovery" , Chem. Soc. Rev. , 2020 , 49 , 3262-3277.  (b) Adam P. Treder, Jennifer L. Hickey, Marie-Claude J. Tremblay, Serge Zaretsky, Conor C. G. Scully, John Mancuso, Annie Doucet, Andrei K. Yudin, and Eric Marsault, "Solid‐Phase Parallel Synthesis of Functionalised Medium‐to‐Large Cyclic Peptidomimetics through Three‐Component Coupling Driven by Aziridine Aldehyde Dimers ", Chem. Eur. J.  2015 , 21 , 9249-9255. DÍA, HORA y LUGAR : Lunes 12 de abril de 2021, 18:00 h, Plataforma MEET GOOGLE. Link :  meet.google.com/bfh-poxv-bso RESUMEN :  (a) The art of transforming peptides into drug leads is still a dynamic and fertile field in medicinal chemistry and drug discovery. Peptidomimetics can respond to peptide lim...

SEMINARIO QUÍMICA ORGÁNICA 05-04-21 EXPOSITOR : Lic. Federico Dezotti TÍTULO :  " Evolution of a Strategy for the Enantioselective Synthesis of (−)-Cajanusine " FUENTE :   Renyu Guo, Brittany P. Witherspoon, and M. Kevin Brown J. Am. Chem. Soc. 2020 , 142 , 5002–5006. https://pubs.acs.org/doi/10.1021/jacs.0c00359 DÍA, HORA y LUGAR : Lunes 5 de abril de 2021, 18:00 h, Plataforma MEET GOOGLE. Link :  meet.google.com/bfh-poxv-bso RESUMEN : The first enantioselective synthesis of (−)-cajanusine is presented. Key features of the route include a rapid synthesis of the [4.2.0]bicyclooctane core by an enantioselective isomerization/stereoselective [2+2]-cycloaddition strategy as well as prominent use of catalytic methods for bond construction. The evolution of the approach is also presented that highlights unexpected roadblocks and how novel solutions were developed.

SEMINARIO QUÍMICA ORGÁNICA 14-12-20 EXPOSITOR : Lic. Maribel Oriana Marcarino TÍTULO :   "From desktop to benchtop with automated computational workflows for computer-aided design in asymmetric catalysis" FUENTE :   Mihai Burai Patrascu, Joshua Pottel, Sharon Pinus, Michelle Bezanson, Per-Ola Norrby & Nicolas Moitessier Nature Catalysis , 3 , 574–584, 2020 .  https://www.nature.com/articles/s41929-020-0468-3 . DÍA, HORA y LUGAR : Lunes 14 de diciembre de 2020, 18:00 h, Plataforma MEET GOOGLE. Link :  meet.google.com/bfh-poxv-bso RESUMEN : The organic chemist’s toolbox is vast, with technologies to accelerate the synthesis of novel chemical matter. The field of asymmetric catalysis is one approach to accessing new areas of chemical space and computational power is today sufficient to assist in this exploration. Unfortunately, existing techniques generally require computational expertise and are therefore underutilized in synthetic chemistry. Here we present our p...

SEMINARIO QUÍMICA ORGÁNICA 30-11-20 EXPOSITOR : Prof. Dr. Ernesto G. Mata TÍTULO : "Time Economy in Total Synthesis" FUENTE :   Hayashi, Y. J. Org. Chem. 2020 , ASAP, https://doi.org/10.1021/acs.joc.0c01581 , y referencias allí citadas. DÍA, HORA y LUGAR : Lunes 30 de noviembre de 2020, 18:00 h, Plataforma MEET GOOGLE. Link :  meet.google.com/bfh-poxv-bso RESUMEN :   It is often said that “time is money”. This is certainly true in a multistep synthesis when a high-valued product or set of products is needed urgently. Fulfilling this need requires the sensible balancing of atom economy, step economy, and redox economy with the time taken to make the product. In this age of flu-based pandemics, the need for rapid provision of effective therapeutic agents makes the importance of “time economy” particularly clear. In this work, the importance of time economy in total synthesis is described, as well as the general considerations underlining the timely production of desired mo...

SEMINARIO QUÍMICA ORGÁNICA 16-11-20 EXPOSITOR : Lic. Florencia Cámpora TÍTULO : " Síntesis Electro-orgánica" FUENTE :  (a)  Cian Kingston, Maximilian D. Palkowitz, Yusuke Takahira, Julien C. Vantourout, Byron K. Peters, Yu Kawamata, and Phil S. Baran, Acc. Chem. Res.   2020 ,  53 , 72-83. (b)  Dennis Pollok and Siegfried R. Waldvogel, Chem. Sci. , 2020 , Advance Article.   DÍA, HORA y LUGAR : Lunes 16 de noviembre de 2020, 18:00 h, Plataforma MEET GOOGLE. Link :  meet.google.com/bfh-poxv-bso RESUMEN :   The fierce limitation of fossil fuels and finite ressources influence the scientific community reconsidering chemical synthesis and establishing sustainable techniques. Several auspicious methods have emerged, whereas electro-organic conversions attract particular attention from the international academia and industry as environmentally begnin and cost-effective technique. An easy application, precise control, and safe conversion of substrates with...