SEMINARIO QUÍMICA ORGÁNICA 24-6-24 EXPOSITOR : Qco. Miguel Villarreal Parra TÍTULO : " Nitro-Group-Containing Drugs " FUENTE : DOI: https://doi.org/10.1021/acs.jmedchem.8b00147 Kunal Nepali, Hsueh-Yun Lee, and Jing-Ping Liou* J. Med. Chem. 2019, 62, 6, 2851–2893. DÍA, HORA y LUGAR : Lunes 24 de junio de 2024, 14:00 h, Aula 18 y virtual. Modalidad virtual, Link : meet.google.com/hjn-ygro-twf ( Plataforma MEET GOOGLE) Resumen : The nitro group is considered to be a versatile and unique functional group in medicinal chemistry. Despite a long history of use in therapeutics, the nitro group has toxicity issues and is often categorized as a structural alert or a toxicophore, and evidence related to drugs containing nitro groups is rather contradictory. In general, drugs containing nitro groups have been extensively associated with mutagenicity and genotoxicity. In this context, efforts toward the structure–mutagenicity or structure–genotoxicity relationsh...
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