13º SEMINARIO QUÍMICA ORGÁNICA IQUIR 2022

SEMINARIO QUÍMICA ORGÁNICA 25-07-22

EXPOSITOR: Dra. María Sol Ballari

TÍTULO: "Reacciones aza Paternò-Büchi intramoleculares de alquenos desactivados, mediadas por luz visible".

FUENTE: : Blackmun, D. E.; Chamness, S. A.; Schindler, C. S. Org. Lett. 2022, 24, 3053–3057. https://doi.org/10.1021/acs.orglett.2c01008.

DÍA, HORA y LUGAR: Lunes 25 de julio de 2022, 14:00 h. Plataforma MEET GOOGLE.

Link: meet.google.com/bfh-poxv-bso

RESUMEN: Azetidines are of particular interest in medicinal chemistry for their favorable properties, including increased resistance to oxidative metabolism and lower lipophilicity. The recent development of [2 + 2] reactions has signiﬁcantly expanded the limited repertoire of methods for azetidine synthesis, but access to more complex architectures still requires further development. Herein, we report a visible-light-enabled intramolecular [2 + 2] cycloaddition of unactivated alkenes that proved previously unreactive to access tricyclic azetidines with 3D complex structures and high levels of saturation.

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