26° SEMINARIO QUÍMICA ORGÁNICA IQUIR 2022

SEMINARIO QUÍMICA ORGÁNICA 07-11-22

EXPOSITOR: Lic. Carmela A. Crespo Guridi

TÍTULO: "Total Syntheses of Strasseriolide A and B, Antimalarial Macrolide Natural Products".

FUENTE: Leah J. Salituro, Jessica E. Pazienza, and Scott D. Rychnovsky. Org. Lett. 2022, 24, 5, 1190–1194.

DÍA, HORA y LUGAR: Lunes 7 de noviembre de 2022, 15:00 h, Aula 16 FBIOYF.

Modalidad virtual, Link: meet.google.com/hjn-ygro-twf (Plataforma MEET GOOGLE)

RESUMEN: The first total syntheses of Strasseriolide A and B have been accomplished. Strasseriolide B shows potent activity against the wild-type malaria parasite Plasmodium falciparum and good activity against a chloroquine-resistant strain. A convergent strategy was envisioned with an aldehyde-acid fragment and a vinyl iodide-alcohol fragment. Both fragments were prepared using chiral pool starting materials. They were combined with a Yamaguchi esterification and cyclized with a Nozaki-Hiyama-Kishi reaction. Strasseriolide B was assembled in a 16-step LLS.

Comentarios

Entradas populares de este blog

24° SEMINARIO QUÍMICA ORGÁNICA IQUIR 2024

SEMINARIO QUÍMICA ORGÁNICA 11-11-24 EXPOSITOR : Qca. Paula Paz Armero TÍTULO : " Total synthesis of (±)‐decursivine via BINOL‐phosphoric acid catalyzed tandem oxidative cyclization ". FUENTE : PrakashT. Parvatkar, Eugene S. Smotkin & Roman Manetsc, Scientific Reports volume 11, Article number: 19915 (2021) DÍA, HORA y LUGAR : Lunes 11 de noviembre de 2024, 14:00 h, Aula 18 y virtual. Modalidad virtual, Link : meet.google.com/hjn-ygro-twf ( Plataforma MEET GOOGLE) Resumen : The synthesis of tetracyclic indole alkaloid (±)-decursivine was accomplished using BINOL-phosphoric acid catalyzed tandem oxidative cyclization as a key step with (bis(trifuoroacetoxy)iodo)benzene (PIFA) as an oxidizing agent. This represents one of the shortest and highest yielding routes for the synthesis of (±)-decursivine from readily available starting materials.

18° SEMINARIO QUÍMICA ORGÁNICA IQUIR 2024

SEMINARIO QUÍMICA ORGÁNICA 16-9-24 EXPOSITOR : Dr. Enrique L. Larghi TÍTULO : " Total Synthesis of Isoxeniolide A " FUENTE : Leo Betschart and Karl-Heinz Altmann. Angew. Chem. Int. Ed. 2024, 63, e202315423, DOI: 10.1002/anie.202315423. DÍA, HORA y LUGAR : Lunes 16 de septiembre de 2024, 14:00 h, Aula 18 y virtual. Modalidad virtual, Link : meet.google.com/hjn-ygro-twf ( Plataforma MEET GOOGLE) Resumen : The total synthesis of the xenicane-type marine natural product isoxeniolide A has been accomplished through a ring-opening/ring-closing metathesis sequence and an intramolecular Nozaki–Hiyama–Kishi (NHK) reaction to forge the nine-membered ring as the key enabling steps. The NHK cyclization was highly diastereoselective and provided the oxabicyclo[7.4.0]tridecene core of isoxeniolide A as a single stereoisomer.

10° SEMINARIO QUÍMICA ORGÁNICA IQUIR 2024

SEMINARIO QUÍMICA ORGÁNICA 24-6-24 EXPOSITOR : Qco. Miguel Villarreal Parra TÍTULO : " Nitro-Group-Containing Drugs " FUENTE : DOI: https://doi.org/10.1021/acs.jmedchem.8b00147 Kunal Nepali, Hsueh-Yun Lee, and Jing-Ping Liou* J. Med. Chem. 2019, 62, 6, 2851–2893. DÍA, HORA y LUGAR : Lunes 24 de junio de 2024, 14:00 h, Aula 18 y virtual. Modalidad virtual, Link : meet.google.com/hjn-ygro-twf ( Plataforma MEET GOOGLE) Resumen : The nitro group is considered to be a versatile and unique functional group in medicinal chemistry. Despite a long history of use in therapeutics, the nitro group has toxicity issues and is often categorized as a structural alert or a toxicophore, and evidence related to drugs containing nitro groups is rather contradictory. In general, drugs containing nitro groups have been extensively associated with mutagenicity and genotoxicity. In this context, efforts toward the structure–mutagenicity or structure–genotoxicity relationsh...

SEMINARIOS AREA QUÍMICA ORGÁNICA FBIOYF/IQUIR

Buscar este blog