18° SEMINARIO QUÍMICA ORGÁNICA IQUIR 2023

SEMINARIO QUÍMICA ORGÁNICA 25-09-23

EXPOSITOR: Farm. Marianela G. Pizzio

TÍTULO: "Photocatalytic C-H Functionalization of Nitrogen Heterocycles Mediated by a Redox Active Protecting Group"

FUENTE: Marianela G. Pizzio, Ernesto G. Mata, Philippe Dauban, and Tanguy Saget, EJOC, e202300616

DÍA, HORA y LUGAR: Lunes 25 de septiembre de 2023, 14:00 h, Aula 18 y virtual.

Modalidad virtual, Link: meet.google.com/hjn-ygro-twf (Plataforma MEET GOOGLE)

Resumen: Herein, we report a photocatalytic strategy for the C-H functionalization of saturated azaheterocycles under mildconditions with only one equivalent of starting material. Our strategy is based on a redox active benzamide protecting group that is activated via a halogen-atom transfer (XAT) process to trigger the formation of an α-amino radical. This nucleophilic radical intermediate was then engaged in Giese additions and radical cross couplings to afford C􀀀 H alkylated and arylated products.