SEMINARIOS AREA QUÍMICA ORGÁNICA FBIOYF/IQUIR

SEMINARIO QUÍMICA ORGÁNICA 10-8-26 EXPOSITOR : Dr. Iván Cortés TÍTULO :   "Nickel Catalysis via SH2 Homolytic Substitution: The Double Decarboxylative Cross-Coupling of Aliphatic Acids " FUENTE :     Artem V. Tsymbal, Lorenzo Delarue Bizzini, David W. C. MacMillan; Nickel Catalysis via SH2 Homolytic Substitution: The Double Decarboxylative Cross-Coupling of Aliphatic Acids. Journal American Chemical Society 23 November 2022; 144 (46): 21278–21286. https://doi.org/10.1021/jacs.2c08989 . DÍA, HORA y LUGAR : Lunes 10 de agosto de 2026, 14:00 h, Aula de graduados y virtual. Modalidad virtual, Link : meet.google.com/wpi-ujuz-rok. Resumen : Cross-coupling platforms are traditionally built around a sequence of closed-shell steps, such as oxidative addition, transmetalation, and reductive elimination. Herein, we describe a dual photo/nickel catalytic manifold that performs cross-coupling via a complementary sequence involving free radical generation, radical sorting via selecti...

SEMINARIO QUÍMICA ORGÁNICA 3-8-26 EXPOSITOR : Lic. Enzo Centurión TÍTULO : " Ladderanes: stepping up as nonclassical ortho-substituted benzene bioisosteres " FUENTE :    Adak, S. et al. Ladderanes: stepping up as nonclassical ortho-substituted benzene bioisosteres. J. Am. Chem. Soc. 148, 23078–23087 (2026). https://doi.org/10.1021/jacs.6c05064. DÍA, HORA y LUGAR : Lunes 3 de agosto de 2026, 14:00 h, Aula de graduados y virtual. Modalidad virtual, Link : meet.google.com/wpi-ujuz-rok. Resumen :  Modulating the physicochemical properties of small-molecule active pharmaceutical ingredients (APIs) is a vital component of the drug discovery process. In recent years, investigations of the synthesis and application of saturated isosteres for aromatic rings have been growing and have often been shown to improve the properties of an API in matched pairs analysis. While saturated isosteres for para-substituted aromatic rings are well-established, replacing ortho-substituted rings,...

SEMINARIO QUÍMICA ORGÁNICA 27-7-26 EXPOSITOR :  Lic. Matías Krivoy TÍTULO : " Photochemical permutation of thiazoles, isothiazoles and other azoles " FUENTE :   Roure, B., Alonso, M., Lonardi, G. et al. Photochemical permutation of thiazoles, isothiazoles and other azoles. Nature 637, 860–867 (2025). https://doi.org/10.1038/s41586-024-08342-8 . DÍA, HORA y LUGAR : Lunes 27 de julio de 2026, 14:00 h, Aula de graduados y virtual. Modalidad virtual, Link : meet.google.com/wpi-ujuz-rok. Resumen : Thiazoles and isothiazoles are privileged motifs in drug and agrochemical discovery. The synthesis of these derivatives is generally approached, designed and developed on a case-by-case basis. Sometimes, the lack of robust synthesis methods to a given target can pose considerable difficulties or even thwart the preparation of specific derivatives for further study. Here we report a conceptually different approach in which photochemical irradiation can be used to alter the structure o...

SEMINARIO QUÍMICA ORGÁNICA 29-6-26 EXPOSITOR :  Qco. José Vaz Cardoso Machado TÍTULO : " Design, Synthesis, and Trypanosomicidal Evaluation of EugenolBased Azole Hybrids: Discovery of an In Vitro Active and Selective Compound. " FUENTE :   Qco.  José Vaz Cardoso Machado et al. , ACS Omega 2025 , 10 , 36, 41958–41974. DÍA, HORA y LUGAR : Lunes 29 de junio de 2026, 14:00 h, Aula de graduados y virtual. Modalidad virtual, Link : meet.google.com/wpi-ujuz-rok. Resumen :  Chagas disease, caused by Trypanosoma cruzi, remains a major public health concern in Latin America and beyond, with limited treatment options and high morbidity in chronic stages. Currently, benznidazole remains the first-line therapy for Chagas disease but exhibits considerable limitations, including dose-dependent toxicity and poor efficacy in long-term infections. In response to the pressing need for safer and more effective therapies, this study reports the design, synthesis, and biological evaluati...

SEMINARIO QUÍMICA ORGÁNICA 8-6-26 EXPOSITOR : Qco. Liddier Pérez Hincapié TÍTULO : " Reacción tricomponente A3 catalizada por complejos Au(I) y Au(III) con ligandos NHC hidrosolubles " FUENTE :   Trabajo de Investigación del expositor. DÍA, HORA y LUGAR : Lunes 8 de junio de 2026, 14:00 h, Aula de graduados y virtual. Modalidad virtual, Link : meet.google.com/wpi-ujuz-rok. Resumen : Se evaluó una familia de complejos de oro(I) y oro(III) con ligandos carbeno N-heterocíclicos (NHC) hidrosolubles en la reacción tricomponente A3 entre benzaldehído, piperidina y fenilacetileno, con el fin de analizar la influencia del estado de oxidación del metal y del entorno estérico del ligando sobre la actividad catalítica en medio acuoso. El impedimento estérico se cuantificó mediante el parámetro de volumen enterrado (%VBur). Los complejos de oro(III) mostraron una clara superioridad, con rendimientos del 96-98% en agua a 70 °C, frente al 20-41% de sus análogos de oro(I). Los complejos c...

SEMINARIO QUÍMICA ORGÁNICA 1-6-26 EXPOSITORA : Farm. Matías Borgogno TÍTULO : " The Discovery of RGH-706, a Highly Efficacious MCH1 Receptor Antagonist, for the Treatment of Obesity and Insatiable Hunger . " FUENTE :    J. Med. Chem. 2026, 69, 8, 8722–8738.  https://doi.org/10.1021/acs.jmedchem.5c02708 DÍA, HORA y LUGAR : Lunes 1 de junio de 2026, 14:00 h, Aula de graduados y virtual. Modalidad virtual, Link : meet.google.com/wpi-ujuz-rok. Resumen : The discovery and characterization of a novel 2,3,4,5-tetrahydro-1H-[1,4]diazepino[1,7-a]indole derivative MCH1 receptor antagonist (37) is disclosed. Starting from our previously investigated pyrazino[1,2-a]indole series and utilizing a scaffold hopping strategy, pyrimidine- and 1,4-diazepine-fused indole derivatives were designed and synthesized. Among these, only the prototype molecule containing the 2,3,4,5-tetrahydro-1H-[1,4]diazepino[1,7-a]indole scaffold emerged as a chemically stable and potent MCHR1 antagonist. Pre...

SEMINARIO QUÍMICA ORGÁNICA 18-5-26 EXPOSITORA : Lic. Mauro Palumbo TÍTULO : " Studies Toward the Total Synthesis of Gliomasolide C ". FUENTE :  Sk Md Tarik Aziz, Subhash Ghosh. ChemistrySelect, 2026; 11: e0742 https://doi.org/10.1002/slct.202507426. DÍA, HORA y LUGAR : Lunes 18 de mayo de 2026, 14:00 h, Aula de graduados y virtual. Modalidad virtual, Link : meet.google.com/wpi-ujuz-rok. Resumen :   This article describes the synthetic studies of gliomasolide C utilizing D-mannitol as a chiral pool material. Julia–Kocienski olefina- tion and Noyori asymmetric reduction were employed to synthesize an advanced intermediate, from which two key precursors for ring-closing metathesis and intramolecular Horner–Wadsworth–Emmons olefination were prepared. Unfortunately, both ring- closing metathesis and Horner–Wadsworth–Emmons olefination were unsuccessful in constructing the desired 14-membered ( E )- α,β-macrolactone core.

SEMINARIO QUÍMICA ORGÁNICA 11-5-26 EXPOSITORA :  Dra.  Carina M. L. Delpiccolo TÍTULO :   " Idler Compounds: A Simple Protocol for Openly Sharing Fridge Contents for Cross-Screening ". FUENTE : Rebecka Isaksson, Eve M. Carter, Charlotte K. Hind, J. Mark Sutton, Hazel Rudgyard, Adam H. Roberts, Christopher W. Moon, Yinuo Wang, Todd Group Researchers, Sandra Codony, Antón L. Martínez, Joanna Bacon, and Matthew H. Todd J. Med. Chem. , 2026 , 69 , 2453-2461. DÍA, HORA y LUGAR : Lunes 11 de mayo de 2026, 14:00 h, Aula de graduados y virtual. Modalidad virtual, Link :  meet.google.com/wpi-ujuz-rok. Resumen : Academic drug discovery laboratories tend to accumulate collections of compounds with great potential value that merely reside in fridges and freezers. Cross screening these libraries against alternative targets holds significant potential for uncovering novel hits, but in the academic setting compound collections are rarely used, and shared, in this way. We present a...

SEMINARIO QUÍMICA ORGÁNICA 4-5-26 EXPOSITOR :  Qco.  Miguel R. Villarreal Parra TÍTULO :   " Quinazolin‐4(3H)‐One‐Based New Glitazones as Dual Inhibitors of α‐Glucosidase and Aldose Reductase: Comprehensive Approaches for Managing Diabetes Mellitus and Its Complications ". FUENTE : Tokalı, F.S., Demir, Y., Ateşoğlu, Ş., Tokalı, P. and Şenol, H. Archiv der Pharmazie, 2025, 358: e70033 https://doi.org/10.1002/ardp.70033 . DÍA, HORA y LUGAR : Lunes 4 de mayo de 2026, 14:00 h, Aula de graduados y virtual. Modalidad virtual, Link :  meet.google.com/wpi-ujuz-rok. Resumen :   A series of novel glitazones containing thiazolidine-2,4-dione and quinazolin-4(3H)-one moieties were synthesized to explore their potential as dual inhibitors of aldose reductase (ALR2) and α-glucosidase (α-Glu), two key enzymes involved in diabetes and its complications. In vitro assays revealed that compounds 8 (cyclohexyl substituted), 9 (phenethyl substituted), and 11 (phenyl substituted) e...

SEMINARIO QUÍMICA ORGÁNICA 27-4-26 EXPOSITOR :  Qco.  Arturo Mendoza Salgado TÍTULO :   " Total Synthesis of (±)-Cristaxenicin A: Construction of Nine-Membered Ring by Eschenmoser–Claisen/Cope Rearrangement Cascade ". FUENTE :   W.Kiuchi, Y.Tsunoda, K.Ishikura, K.Kato, J.Takino, T.Suzuki, K.Tanino, Angew. Chem. Int. Ed.  2026 , 65 , e24855. https://doi.org/10.1002/anie.202524855 . DÍA, HORA y LUGAR : Lunes 27 de abril de 2026, 14:00 h, Aula de graduados y virtual. Modalidad virtual, Link :  meet.google.com/wpi-ujuz-rok. Resumen :   Cristaxenicin A, a natural marine product with a skeleton consisting of a nine-membered carbocycle fused with a dihydropyran ring, displays strong antiprotozoal activity against Leishmania amazonensis and Trypanosoma congolense. The synthesis of cristaxenicin A is challenging because of its unique oxidation pattern at C11 and C20, the cis-cyclononane with a C5─C6 double bond, and the C1─C19 alkene moiety functionalized ...

SEMINARIO QUÍMICA ORGÁNICA 20-4-26 EXPOSITOR :  Dr. Ernesto G. Mata TÍTULO :   " Total Syntheses of Bryostatins ". FUENTE :   Guo, Q., Yang, Y., Zhang, H., Wang, D., Li, B., Jiang, D., ... & Song, Z. Angewandte Chemie , 2025 , 137 (14), e202423465. DÍA, HORA y LUGAR : Lunes 20 de abril de 2026, 14:00 h, Aula de graduados y virtual. Modalidad virtual, Link :  meet.google.com/wpi-ujuz-rok. Resumen : Bryostatin 1 34, produced by a bacterial symbiont of the marine bryozoan Begula neritina, has shown promise for the treatment of Alzheimer’s disease. This work reports the divergent total syntheses of bryostatins, obtaining 1.5 g of bryostatin 1 in the final three steps. Key methods include Ni-catalyzed reductive cross-coupling, flow-assisted light-induced radical addition, and a Prins cyclization for cis-Z selectivity. The syntheses require 20–22 linear steps (33–35 total) with overall yields of 3.3–4.5%.

SEMINARIO QUÍMICA ORGÁNICA 13-4-26 EXPOSITOR :  Lic. Darián Vazquez TÍTULO :   " Total syntheses of Tetrodotoxin and 9-epiTetrodotoxin ". FUENTE : Chen, P., Wang, J., Zhang, S. et al. Total syntheses of Tetrodotoxin and 9-epiTetrodotoxin. Nat Commun 15, 679 (2024). https://doi.org/10.1038/s41467-024-45037-0 . DÍA, HORA y LUGAR : Lunes 13 de abril de 2026, 14:00 h, híbrido. Modalidad presencial (Aula de graduados) y virtual, Link :  meet.google.com/wpi-ujuz-rok. Resumen : Tetrodotoxin and congeners are specific voltage-gated sodium channel blockers that exhibit remarkable anesthetic and analgesic effects. Here, we present a scalable asymmetric syntheses of Tetrodotoxin and 9-epiTetrodotoxin from the abundant chemical feedstock furfuryl alcohol. The optically pure cyclohexane skeleton is assembled via a stereoselective Diels-Alder reaction. The dense heteroatom substituents are established sequentially by a series of functional group interconversions on highly oxygenated ...

SEMINARIO QUÍMICA ORGÁNICA 6-4-26 EXPOSITOR : Lic. Lina V. López López TÍTULO :   " Late-Stage Functionalization of Amino Acids and Peptides ". FUENTE :  Trabajo de investigación de la presentadora. DÍA, HORA y LUGAR : Lunes 6 de abril de 2026, 14:00 h, Aula 12 y virtual. Modalidad virtual, Link :  meet.google.com/wpi-ujuz-rok. Resumen :  El seminario que se llevará a cabo presenta los resultados de la pasantía realizada el año pasado a través de una beca otorgada por la OPCW en Gif-Sur-Yvette (Francia), en el ICSN, bajo la supervisión del Dr. Philippe Dauban. El objetivo de este trabajo es establecer condiciones óptimas para la funcionalización selectiva de enlaces C–H en diversos aminoácidos, con el fin de extender estas metodologías a sistemas más complejos, como los péptidos.

SEMINARIO QUÍMICA ORGÁNICA 15-12-25 EXPOSITOR :   Dr. Tonino G. Adessi Cofré TÍTULO :   " Biomimetic synthesis of Sinularia meroterpenoids and photochemical reactivity of capillobenzopyranol ". FUENTE : French, S. A., Peralta, R. A., & George, J. H. (2025). Biomimetic synthesis of Sinularia meroterpenoids and photochemical reactivity of capillobenzopyranol. Organic & Biomolecular Chemistry. https://doi.org/10.1039/D5OB01430A DÍA, HORA y LUGAR : Lunes 15 de diciembre de 2025, 14:00 h, Aula 16 y virtual. Modalidad virtual, Link :  meet.google.com/wpi-ujuz-rok  ( Plataforma MEET GOOGLE) Resumen :  Motivated by a biosynthetic proposal which suggests a chemical relationship between capilloquinol and capillobenzopyranol, our studies report the first synthesis of their probable biogenetic precursors, furanoquinol and furanoquinone. A bioinspired cascade using an ortho-quinone methide intermediate derived from furanoquinone was attempted to construct the spiroc...

SEMINARIO QUÍMICA ORGÁNICA 17-11-25 EXPOSITOR :   Dra. Nadia  L. Martiren TÍTULO :   " Discovery of the Clinical Candidate S‑892216: A Second-Generation of SARS-CoV‑2 3CL Protease Inhibitor for Treating COVID-19 ". FUENTE : Yuto Unoh,* Keiichiro Hirai, Shota Uehara, Sho Kawashima, Haruaki Nobori, Jun Sato, Hiromitsu Shibayama, Akihiro Hori, Kenji Nakahara, Kana Kurahashi, Masayuki Takamatsu, Shiho Yamamoto, Qianhui Zhang, Miki Tanimura, Reiko Dodo, Yuki Maruyama, Hirofumi Sawa, Ryosuke Watari, Tetsuya Miyano, Teruhisa Kato, Takafumi Sato, and Yuki Tachibana "Discovery of the Clinical Candidate S‑892216: A Second-Generation of SARS-CoV‑2 3CL Protease Inhibitor for Treating COVID-19" J. Med. Chem. 2025, 68, 21099−21119. DOI: https://doi.org/10.1021/acs.jmedchem.5c00754 DÍA, HORA y LUGAR : Lunes 17 de noviembre de 2025, 14:00 h, Aula 18 y virtual. Modalidad virtual, Link :  meet.google.com/hjn-ygro-twf  ( Plataforma MEET GOOGLE) Resumen :  The coronavirus di...

SEMINARIO QUÍMICA ORGÁNICA 10-11-25 EXPOSITOR :   Qco.  José A. Pérez Mendoza TÍTULO :   " Stepwise or concerted? One-bond- nucleophilicity and -electrophilicity parameters for the mechanistic analysis of 1,3-dipolar cycloadditions ". FUENTE :  Mayr, Herbert, Li, Le, Mayer, Robert J. and Ofial, Armin R.. "Stepwise or concerted? One-bond-nucleophilicity and -electrophilicity parameters for the mechanistic analysis of 1,3-dipolar cycloadditions" Pure and Applied Chemistry . https://doi.org/10.1515/pac-2025-0449 . DÍA, HORA y LUGAR : Lunes 10 de noviembre de 2025, 14:00 h, Aula 18 y virtual. Modalidad virtual, Link :  meet.google.com/hjn-ygro-twf  ( Plataforma MEET GOOGLE) Resumen :   Este trabajo presenta un método cuantitativo para diferenciar mecanismos de cicloadición 1,3-dipolar, midiendo nuevos parámetros de reactividad (N, sN, y E) para diazoalcanos como el metil diazoacetato y el dimetil diazomalonato . Con estos parámetros, se utilizó una ecuac...

SEMINARIO QUÍMICA ORGÁNICA 27-10-25 EXPOSITOR :   Lic. Andrés Santarelli TÍTULO :   " Fotocatalizadores para la producción de hidrógeno: materiales y estrategias para mejorar su eficiencia ". FUENTE :  Abhishek B., Jayarama A., Arjun Sunil Rao, Sanjog S. Nagarkar, Arnab Dutta, Siddhartha P. Duttagupta, Sriganesh S. Prabhu, Richard Pinto. “Challenges in photocatalytic hydrogen evolution: Importance of photocatalysts and photocatalytic reactors”. International Journal of Hydrogen Energy 81 ( 2024 ) 1442–1466. Mengyao C., Guang-en F., Wenkai Z., Tao Z. “Effective Strategies in Covalent Organic Frameworks for Enhanced Photocatalytic Hydrogen Production”. Chemistry- A European Journal 31 ( 2025 ) 1-17. . DÍA, HORA y LUGAR : Lunes 27 de octubre de 2025, 14:00 h, Aula 18 y virtual. Modalidad virtual, Link :  meet.google.com/hjn-ygro-twf  ( Plataforma MEET GOOGLE) Resumen :   El hidrógeno, como vector energético verde, se ha convertido en uno de los candidatos más...

SEMINARIO QUÍMICA ORGÁNICA 20-10-25 EXPOSITOR :   Lic. Lucas Passaglia TÍTULO :   " Inteligencia artificial al servicio de la elucidación estructural ". FUENTE :  Kim, H.W., Zhang, C., Reher, R. et al. "DeepSAT: Learning Molecular Structures from Nuclear Magnetic Resonance Data." J. Cheminform 15, 71 ( 2023 ). https://doi.org/10.1186/s13321-023-00738-4. Frank Hu, Michael S. Chen, Grant M. Rotskoff, Matthew W. Kanan, and Thomas E. Markland "Accurate and Efficient Structure Elucidation from Routine One-Dimensional NMR Spectra Using Multitask Machine Learning"  ACS Central Science, 2024 10 (11), 2162-2170. DOI: 10.1021/acscentsci.4c01132 . DÍA, HORA y LUGAR : Lunes 20 de octubre de 2025, 14:00 h, Aula 18 y virtual. Modalidad virtual, Link :  meet.google.com/hjn-ygro-twf  ( Plataforma MEET GOOGLE) Resumen : La inteligencia artificial ha transformado la forma de abordar los problemas científicos, y la química no es la excepción. Desde la predicción de estruc...

SEMINARIO QUÍMICA ORGÁNICA 13-10-25 EXPOSITOR :   Dra. Silvina C. Pellegrinet TÍTULO :   " Hydride Shuttle Catalysis: From Conventional to Inverse Mode ". FUENTE :  Iakovos Saridakis, Immo Klose, Benjamin T. Jones, and Nuno Maulide  JACS Au 2024, 4, 3358−3369 . DÍA, HORA y LUGAR : Lunes 13 de octubre de 2025, 14:00 h, Aula 18 y virtual. Modalidad virtual, Link :  meet.google.com/hjn-ygro-twf  ( Plataforma MEET GOOGLE) Resumen :  Hydride shuttle catalysis has emerged as a powerful synthetic platform, enabling the selective formation of C–C bonds to yield sp3-rich structures. By virtue of the compelling reactivity of sterically encumbered Lewis acids from the frustrated Lewis pair regime, hydride shuttle catalysis enables the regioselective functionalization of alkyl amines at either the α- or β-position. In contrast to classical Lewis acid reactivity, the increased steric hindrance prevents interaction with the Lewis basic amine itself, instead leading ...

SEMINARIO QUÍMICA ORGÁNICA 08-10-25 EXPOSITOR :   Lic. Milagros Amichetti TÍTULO :   " Estudios en la Frontera de la Química Computacional y la Elucidación Estructural: Evaluación de Métodos y Desarrollo de Estrategias para Sistemas Complejos". FUENTE :  Trabajo de investigación de la estudiante de doctorado. DÍA, HORA y LUGAR : Miércoles 8 de octubre de 2025, 15:30 h, virtual. Modalidad virtual, Link :  meet.google.com/hjn-ygro-twf  ( Plataforma MEET GOOGLE) Resumen : El uso de la química computacional para la elucidación estructural se ha incrementado notablemente, siendo el método DP4+ una de las herramientas más destacadas para la asignación estereoquímica. En este trabajo de tesis se han abordado estas metodologías para evaluar y robustecer su aplicabilidad. Esto incluyó, en una primera etapa, la optimización de protocolos computacionales para sistemas flexibles y polihidroxilados, con el fin de superar sesgos conformacionales. En una segunda instancia, se ...